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首页> 外文期刊>Polymers for advanced technologies >Preparation, mechanical properties, and in vitro biocompatibility of novel nanocomposites based on polyhexamethylene carbonate fumarate and nanohydroxyapatite
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Preparation, mechanical properties, and in vitro biocompatibility of novel nanocomposites based on polyhexamethylene carbonate fumarate and nanohydroxyapatite

机译：基于聚六亚甲基碳酸富马酸酯和纳米羟基磷灰石的新型纳米复合材料的制备，力学性能和体外生物相容性

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摘要

Mohammad Ali Shokrgozarc, Sayed Mahmood Rabieed, Mohammad Ataie, Mohammad Imania and Hamid Mirzadehf In the current study a new biodegradable nanocomposite based on poly hexamethylene carbonate fumarate (PHMCF) and nano-sized hydroxyapatite (nano-HA) has been developed. A silane coupling agent g-methacryloxypropyltrimethoxy silane, was used to achieve a good interfacial adhesion between nano-HA and PHMCF matrix. PHMCF with different nano-HA contents were characterized using dynamical mechanical thermal analysis (DMTA) and hardness test. The effect of frequency on storage modulus, glass transition temperature (T_g) and the damping were investigated. In vitro cytotoxicity and proliferation were performed using G292 cell lines by MTT assay. The addition of nano-HA resulted in an increment on the storage modulus and decrement on the damping. Along with improvement in mechanical properties of composites, the addition of nano-HA resulted in enhanced cell proliferation. Following these results, the newly developed nano-PHMCF composite scaffold may be considered for bone tissue engineering applications.
机译：Mohammad Ali Shokrgozarc，Sayed Mahmood Rabieed，Mohammad Ataie，Mohammad Imania和Hamid Mirzadehf在当前研究中，已经开发了一种新的可生物降解的纳米复合材料，该复合材料基于聚碳酸六亚甲基富马酸酯（PHMCF）和纳米羟基磷灰石（nano-HA）。使用硅烷偶联剂g-甲基丙烯酰氧基丙基三甲氧基硅烷在纳米HA和PHMCF基质之间实现良好的界面粘合。使用动态机械热分析（DMTA）和硬度测试对具有不同纳米HA含量的PHMCF进行了表征。研究了频率对储能模量，玻璃化转变温度（T_g）和阻尼的影响。通过MTT试验使用G292细胞系进行体外细胞毒性和增殖。纳米HA的添加导致储能模量增加，阻尼减小。随着复合材料机械性能的改善，纳米HA的加入导致细胞增殖增强。根据这些结果，可以考虑将新开发的纳米PHMCF复合支架用于骨组织工程应用。

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