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首页> 外文期刊>Polymers for advanced technologies >Evaluation of methoxy polyethylene glycolpolylactide diblock copolymers as additive in hypromellose film coating
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Evaluation of methoxy polyethylene glycolpolylactide diblock copolymers as additive in hypromellose film coating

机译：甲氧基聚乙二醇聚丙交酯二嵌段共聚物作为羟丙甲纤维素薄膜包衣添加剂的评价

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This paper deals with a new application of diblock methoxy polyethylene glycol-polylactide block copolymers, a class of synthetic biomaterials largely studied in the pharmaceutical and biomedical fields owing to their favorable properties such as biocompatibility, biodegradability, low immunogenicity, and good mechanical properties. In this work, these materials were evaluated as additives for gastro-soluble pharmaceutical coating aimed to reduce film stiffness and water permeability. Two copolymers with different polylactide chain lengths were synthesized and characterized in term of molecular weight and solid-state properties. A series of free films with different hypromellose/copolymers ratio were prepared and characterized in terms of appearance, components miscibility, plasticity, and water vapor permeability. The obtained results demonstrate that copolymers effectively influence hypromellose film properties according to their concentration and molecular weight. Specifically, the addition of the copolymer with a molecular weight of 6.5 kDa in a ratio hypromellose: polymer 5:1, allowed to obtain films with good appearance, improved plasticization, and water permeability properties. For higher molecular weight, copolymer or different ratios was not possible to observe the improvement of all the properties at the same time. The results also make possible to define the critical features to improve in order to use block copolymers as additive in hypromellose film coating. The availability of new water-soluble additives able to work as plasticizer and moisture sealer in polymeric films represents an important progress not only in the field of pharmaceutical coating but also in that of food coatings, as for example in the formulation of edible films.
机译：本文探讨了二嵌段甲氧基聚乙二醇-聚丙交酯嵌段共聚物的新应用，由于其良好的特性（如生物相容性，生物降解性，低免疫原性和良好的机械性能），一类在药物和生物医学领域进行了广泛研究的合成生物材料。在这项工作中，这些材料被评估为胃溶性药物涂层的添加剂，旨在降低膜的硬度和透水性。合成了两种具有不同聚丙交酯链长的共聚物，并根据分子量和固态性质对其进行了表征。制备了一系列具有不同羟丙甲纤维素/共聚物比率的自由膜，并根据外观，组分互溶性，可塑性和水蒸气渗透性对其进行了表征。所得结果证明，共聚物根据其浓度和分子量有效地影响羟丙甲纤维素膜的性能。具体地，以羟丙甲纤维素：聚合物5∶1的比例加入分子量为6.5kDa的共聚物，可以得到具有良好外观，改善的增塑性和透水性的薄膜。对于较高的分子量，不可能同时观察到共聚物或不同比例的所有性能的改善。结果还可以定义关键的改进特征，以便在羟丙甲纤维素薄膜包衣中使用嵌段共聚物作为添加剂。能够在聚合物薄膜中用作增塑剂和湿气封闭剂的新型水溶性添加剂的可用性，不仅在药物涂层领域，而且在食品涂层领域，例如在配制可食用薄膜方面，都代表着重要的进展。

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