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A quaternary composite fiber membrane for guided tissue regeneration

机译:一种用于组织再生的四元复合纤维膜

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This work reported a novel composite fiber membrane containing poly(1actic-co-glycolic acid)/six-armed poly(epsilon-caprolactone)/hydroxylapatite-grafted poly(L-lactide)/Pluronic F-108 (PLGA/SAPCL/HA-g-PLLA/PF-108) produced by electrospinning. SAPCL, HA-g-PLLA, and PF-108 could be well blended with PLGA to make fibers. Fibrous surface and diameter had little difference in morphology with the change of fibrous component. Compared with simple PLGA, PLGA/SAPCL, or PLGA/SAPCL/HA-g-PLLA fiber membrane, the quaternary composites not only showed the improved mechanics stability but also possessed better hydrophilicity. The quaternary membrane was conductive to accelerate degradation and maintained nice bioactivity. It was not cytotoxicity. These results suggest that the composite fiber membrane may be qualified as guided bone regeneration substrate. Copyright (C) 2015 John Wiley & Sons, Ltd.
机译:这项工作报告了一种新型的复合纤维膜,其中包含聚(1actic-co-乙醇酸)/六臂聚(ε-己内酯)/羟基磷灰石接枝的聚(L-丙交酯)/普流尼克F-108(PLGA / SAPCL / HA- g-PLLA / PF-108)。 SAPCL,HA-g-PLLA和PF-108可以与PLGA很好地混合以制造纤维。纤维表面和直径随纤维成分的变化在形态上几乎没有差异。与简单的PLGA,PLGA / SAPCL或PLGA / SAPCL / HA-g-PLLA纤维膜相比,四元复合材料不仅显示出更高的力学稳定性,而且还具有更好的亲水性。四级膜具有导电性,可加速降解并保持良好的生物活性。这不是细胞毒性。这些结果表明,复合纤维膜可以作为引导骨再生的基质。版权所有(C)2015 John Wiley&Sons,Ltd.

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