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首页> 外文期刊>Polymers research journal >Spectroscopy Studies on the Thermodynamic Interaction of the Thionine Binding of ct-DNA
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Spectroscopy Studies on the Thermodynamic Interaction of the Thionine Binding of ct-DNA

机译：ct-DNA的硫氨酸结合的热力学相互作用的光谱学研究

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摘要

The ct-DNA binding properties of thionine (Th) including binding constant and thermodynamic parameter have been systematically studied by spectrophotometric method. The binding constant and stoichiometry were determined by analysis of optical absorption spectra of the Th dye at various ct-DNA concentrations using SQUAD software. The binding of Th to ct-DNA is quite strong as indicated by remarkable hypochromicity, red shift and equilibrium binding constant (K_b). Van't Hoff plot of 1/T versus lnK_b suggests that the Th dye binds exothermically to ct-DNA which is characterized by large negative enthalpy and entropy changes. This suggests that Th dye possibly bind to ct-DNA via electrostatic by the intercalation mode.
机译：通过分光光度法系统研究了硫氨酸（Th）的ct-DNA结合特性，包括结合常数和热力学参数。通过使用SQUAD软件分析各种ct-DNA浓度下Th染料的光吸收光谱来确定结合常数和化学计量。 Th与ct-DNA的结合非常牢固，表现为显着的低色性，红移和平衡结合常数（K_b）。 Van't Hoff 1 / T与lnK_b的关系图表明Th染料与ct-DNA放热结合，其特征是较大的负焓和熵变。这表明Th染料可能通过嵌入模式通过静电与ct-DNA结合。

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