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首页> 外文期刊>Biomaterials >SYNTHESIS OF PHOSPHOLIPID POLYMERS HAVING A METHANE BOND IN THE SIDE CHAIN AS COATING MATERIAL ON SEGMENTED POLYURETHANE AND THEIR PLATELET ADHESION-RESISTANT PROPERTIES
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SYNTHESIS OF PHOSPHOLIPID POLYMERS HAVING A METHANE BOND IN THE SIDE CHAIN AS COATING MATERIAL ON SEGMENTED POLYURETHANE AND THEIR PLATELET ADHESION-RESISTANT PROPERTIES

机译：侧链上具有甲烷键的磷脂聚合物的合成及其在涂层中的抗血小板粘附性能

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Surface modification of segmented polyurethanes (SPUs) was carried out using new blood compatible polymers having both phospholipid polar groups and urethane bonds in the side chains, The polymers were composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA) and methacrylate with a urethane bond (MU). The MPC copolymers were soluble in ethanol. The SPU membranes were immersed in an ethanol solution of MPC copolymers and dried in vacuo for coating. The surface formed was completely covered with the MPC copolymer which was confirmed by X-ray photoelectron spectroscopic analysis. The polymer coatings were hardly detached in water, ethanol and 40% aqueous solution of ethanol compared with poly(MPC-co-BMA) which did not have the MU moieties. Therefore, the MU moieties had affinity for the SPU. The surface modification of the SPUs suppressed platelet adhesion effectively after contact with platelet-rich plasma for 180 min. [References: 22]
机译：使用新型的血液相容性聚合物对链段聚氨酯（SPU）进行表面改性，该聚合物在侧链中同时具有磷脂极性基团和氨基甲酸酯键。该聚合物由2-甲基丙烯酰氧基乙基磷酰胆碱（MPC），甲基丙烯酸正丁酯（BMA）和具有氨基甲酸酯键（MU）的甲基丙烯酸酯。 MPC共聚物可溶于乙醇。将SPU膜浸入MPC共聚物的乙醇溶液中，并在真空中干燥以进行涂布。形成的表面完全被MPC共聚物覆盖，这通过X射线光电子能谱分析确认。与不具有MU部分的聚（MPC-co-BMA）相比，聚合物涂层在水，乙醇和40％的乙醇水溶液中几乎不分离。因此，MU部分对SPU具有亲和力。在与富含血小板的血浆接触180分钟后，SPU的表面改性有效地抑制了血小板粘附。 [参考：22]

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