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首页> 外文期刊>Poultry Science >Immunopathological effects of ochratoxin A and T-2 toxin combination on broilers
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Immunopathological effects of ochratoxin A and T-2 toxin combination on broilers

机译：曲霉毒素A和T-2毒素组合对肉鸡的免疫病理学影响

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The purpose of this study was to investigate the immunopathological effects of combinations of ochratoxin A (OTA) and T-2 toxin on broilers. Four hundred eighty 1-d-old broilers were randomly assigned to 4 groups, each group consisting of 4 duplicates each with 30 broilers. The 4 groups were fed the following diets for 4 wk: group 1 = basal diet (control, mycotoxin-free); group 2 = basal diet + 2,000 mg/kg of Mycofix Plus; group 3 = basal diet + 0.25 mg/kg of OTA and 0.5 mg/kg of T-2; and group 4 = basal diet + 0.25 mg/kg of OTA and 0.5 mg/kg of T-2 + 2,000 mg/kg of Mycofix Plus. The feeding of OTA-T-2 toxin diets reduced (P < 0.05) the level of anti-Newcastle disease virus antibody titers by 10.4%. When broilers were administered lipopolysaccharide, the results of real-time PCR showed that broilers fed OTA-T-2 toxin reduced the cytokine mRNA expression levels of interleukin-2 and interferon-gamma to some extent but not significantly (P > 0.05). The concentrations of interleukin-2 and interferon-gamma in serum were significantly decreased (P < 0.05) by OTA-T-2 toxin combination. Histopathological studies demonstrated that OTA-T-2 toxin combination caused abnormalities in the thymus, bursa of Fabricius, spleen, and liver. Ochratoxin A-T-2 toxicity could be counteracted by Mycofix Plus partially but not significantly (P > 0.05). The concentrations of OTA and T-2 toxin used in this study are under the maximum tolerated levels recommended by Canadian Food Inspection Agency. Our study clearly put the standard and detoxification method for these toxins into question. We suggest that it may be time to reduce the maximum allowable limits of OTA and T-2 mycotoxins in feeds to improve animal health and the safety of the food chain.
机译：这项研究的目的是研究曲霉毒素A（OTA）和T-2毒素组合对肉鸡的免疫病理学影响。将480只1日龄肉鸡随机分为4组，每组由4个重复样本组成，每组30只肉鸡。 4组分别接受以下饮食，每周4周：第1组=基础饮食（对照，无霉菌毒素）;第2组=基础饮食+ 2,000 mg / kg Mycofix Plus;第3组=基础饮食+ 0.25 mg / kg的OTA和0.5 mg / kg的T-2;第4组=基础饮食+ 0.25 mg / kg的OTA和0.5 mg / kg的T-2 + 2,000 mg / kg的Mycofix Plus。喂食OTA-T-2毒素饮食可使抗新城疫病毒抗体滴度水平降低（P <0.05）10.4％。肉仔鸡服用脂多糖后，实时荧光定量PCR结果显示，喂食OTA-T-2毒素的肉仔鸡在一定程度上降低了白介素2和干扰素-γ的细胞因子mRNA表达水平，但无明显降低（P> 0.05）。 OTA-T-2毒素联合使用可使血清中白细胞介素2和干扰素-γ的浓度显着降低（P <0.05）。组织病理学研究表明，OTA-T-2毒素组合可导致胸腺，法氏囊，脾脏和肝脏异常。 co曲霉毒素A-T-2的毒性可以部分地被Mycofix Plus抵消，但不能被明显地抵消（P> 0.05）。本研究中使用的OTA和T-2毒素的浓度低于加拿大食品检验局建议的最大耐受水平。我们的研究清楚地提出了这些毒素的标准和解毒方法。我们建议可能是时候降低饲料中OTA和T-2霉菌毒素的最大允许限量以改善动物健康和食物链的安全性。

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