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首页> 外文期刊>Poultry Science >The relationship between blood and muscle samples to monitor for residues of the antibiotic enrofloxacin in chickens.
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The relationship between blood and muscle samples to monitor for residues of the antibiotic enrofloxacin in chickens.

机译：血液和肌肉样本之间的关系，以监测鸡中恩诺沙星抗生素的残留量。

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摘要

In 2005, the US Food and Drug Administration withdrew approval for use of enrofloxacin in poultry, thus effectively imposing zero tolerance for residues of this antibiotic in poultry. Conventional residue monitoring for most antibiotics, including enrofloxacin, involves removing poultry carcasses from the processing line and collecting muscle tissues for analysis. Because of the loss of valuable edible products and the difficulties and expense of sampling all the carcasses, only a small portion of carcasses are tested for violative residues. Unlike muscle tissue, blood is readily available from all birds at the beginning of processing and may be used to screen for illegal residues in all poultry carcasses. It is unknown, however, if enrofloxacin concentrations in blood are predictive of muscle concentrations. In an effort to evaluate this relationship, 156 broiler chickens, 5 wk of age, were dosed with either 25 or 50 mug/ml of enrofloxacin for 3 or 7 d, respectively, in the drinking water. Blood and muscle samples were collected at 0, 1, 3, 6, 12, and 24 h (n = 6 birds/group) during the first dosing day, every 48 h during the dosing period, and every 12 h during the withdrawal period for up to 60 h after withdrawal. Enrofloxacin residues were determined in all blood and tissue samples during the dosing periods and in most of the withdrawal period for both doses. These results support the potential to use blood to screen for illegal enrofloxacin residues in edible poultry tissues in an effort to protect the human food supply.
机译：2005年，美国食品和药物管理局（US Food and Drug Administration）撤消了在家禽中使用恩诺沙星的批准，从而有效地对家禽中的这种抗生素残留实行零容忍。大多数抗生素（包括恩诺沙星）的常规残留监测包括从加工线中去除家禽尸体并收集肌肉组织以进行分析。由于有价值的可食用产品的损失以及对所有屠体进行采样的困难和费用，仅对一小部分屠体进行了违规残留测试。与肌肉组织不同，在加工开始时，所有禽类都容易获得血液​​，可用于筛查所有家禽尸体中的非法残留物。然而，尚不清楚血液中的恩诺沙星浓度是否可预测肌肉浓度。为了评估这种关系，在饮用水中分别给156只5周龄的肉鸡分别服用25或50杯/毫升的恩诺沙星3 d或7 d。在第一个给药日的第0、1、3、6、12和24小时（ n = 6只鸡/组）采集血液和肌肉样本，给药期间每48小时采集一次，停药后每12小时停药一次，直至停药后60小时。在两次给药期间和所有停药期的大部分血液和组织样品中均确定了恩诺沙星残留。这些结果支持使用血液来筛查可食用的家禽组织中非法的恩诺沙星残留物以保护人类食物供应的潜力。

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