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Modulation of innate and adaptive immunity by the probiotic Bifidobacterium longum PCB133 in turkeys

机译：益生菌长双歧杆菌PCB133对火鸡的先天和适应性免疫的调节

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The use of protective, probiotic cultures in poultry farming may serve as a useful strategy to improve food product safety from the beginning of the food chain and thus to protect consumer health. The objective of this study was to investigate the effect of the probiotic strain Bifidobacterium longum PCB133 on innate and adaptive immune responses in turkeys beginning at 2 wk of age, under farming conditions. The vaccination efficiency against Newcastle disease virus served as the primary endpoint. At 2 wk of age, male turkeys (British United Turkey Big 6 strain) were randomly assigned to the control (n = 25) or probiotic group (n = 25). Turkeys in the probiotic group received the probiotic B. longum PCB133 (at least 3 x 10(7) cfu/d) incorporated into the daily feed ration for 5 wk, until slaughter at 7 wk of age. At the beginning of the probiotic intervention, birds in both groups were vaccinated against Newcastle disease. Birds were weighed weekly throughout the intervention period, and finally blood sera and heparinized blood were collected for immune function tests (lymphocyte proliferation, phagocytosis, respiratory burst), and for the determination of Newcastle disease virus antibody titers. No effects on BW gain and on the proliferation of blood lymphocytes were elicited by the 5-wk intervention with the probiotic. Concerning the primary endpoint of the study (i.e., specific antibody production as a response to vaccination against Newcastle disease), no adjuvant effect of the probiotic could be determined. In addition, innate immune functions tested were not significantly affected. In conclusion, first scientific evidence on the application of the probiotic strain B. longum PCB133 in turkeys beginning at 2 wk of age does not support an improvement in live performance, humoral immunity, or innate immunity.
机译：在家禽饲养中使用保护性益生菌培养物可作为从食物链开始改善食品安全性并保护消费者健康的有用策略。这项研究的目的是调查在农耕条件下，益生菌长双歧杆菌PCB133对火鸡从2周龄开始对先天和适应性免疫反应的影响。针对新城疫病毒的疫苗接种效率是主要终点。在2周龄时，雄性火鸡（英国联合土耳其Big 6毒株）被随机分配为对照组（n = 25）或益生菌组（n = 25）。益生菌组中的火鸡接受了益生菌长双歧杆菌PCB133（至少3 x 10（7）cfu / d），并按每天5周的饲料比例摄入，直到7周龄被宰杀为止。在益生菌干预开始之初，两组家禽均接种了新城疫疫苗。在整个干预期间，每周对禽类称重，最后收集血样和肝素化血液用于免疫功能测试（淋巴细胞增殖，吞噬作用，呼吸爆发），并用于确定新城疫病毒抗体的滴度。益生菌的5周干预对体重增加和血液淋巴细胞增殖没有影响。关于该研究的主要终点（即，针对针对新城疫的疫苗接种的特异性抗体产生），无法确定益生菌的佐剂作用。此外，测试的先天免疫功能没有受到明显影响。总而言之，关于益生菌长双歧杆菌PCB133在2周龄开始的火鸡中的应用的第一项科学证据不支持活体表现，体液免疫或先天免疫的改善。

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