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首页> 外文期刊>Poultry Science >Immunization with outer membrane protein A from Salmonella enterica serovar Enteritidis induces humoral immune response but no protection against homologous challenge in chickens.
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Immunization with outer membrane protein A from Salmonella enterica serovar Enteritidis induces humoral immune response but no protection against homologous challenge in chickens.

机译：用肠炎沙门氏菌肠炎沙门氏菌的外膜蛋白A免疫可诱导体液免疫反应，但对鸡的同源攻击没有保护作用。

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摘要

Vaccination of poultry is one promising strategy to mitigate Salmonella infection in poultry and, in turn, humans as well. We evaluated the efficacy of outer membrane protein A (OmpA) as a novel vaccine candidate against Salmonella in poultry. Native OmpA purified from Salmonella enterica serovar Enteritidis was mixed with adjuvant and administered intramuscularly to 41-d-old chicks. The vaccinated birds showed no decrease in cecal excretion and tissue colonization compared with the unvaccinated birds after oral challenge with 109 cfu of the homologous strain at 28 d postimmunization. However, this vaccination induced an increased level of serum anti-OmpA IgG. Similar results were obtained in the replication experiments using a recombinant OmpA with single and double doses. For the development of more effective component vaccines for avian salmonellosis, the vaccine efficacy of outer membrane proteins other than OmpA and route of immunization other than parenteral administration should be evaluated with regard to protection and immune responses, including mucosal IgA
机译：家禽疫苗接种是减轻家禽以及人的沙门氏菌感染的一种有前途的策略。我们评估了外膜蛋白A（OmpA）作为针对禽类沙门氏菌的新型候选疫苗的功效。从肠炎沙门氏菌肠炎沙门氏菌中纯化得到的天然OmpA与佐剂混合，并肌肉注射给41日龄的雏鸡。免疫后28 d，用10 9 cfu同源菌株口服攻击后，接种的禽类与未接种的禽类相比，盲肠排泄和组织定植没有减少。但是，这种疫苗接种导致血清抗OmpA IgG水平升高。使用单剂量和双剂量的重组OmpA在复制实验中获得了相似的结果。为了开发更有效的禽沙门氏菌成分疫苗，应就保护和免疫应答（包括粘膜IgA）评估除OmpA以外的外膜蛋白的疫苗功效以及除肠胃外给药以外的免疫途径

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