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Transcellular and paracellular elements of salt chemosensation in toad skin

机译：蟾蜍皮肤中盐化学感知的跨细胞和旁细胞成分

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Dehydrated toads absorb water by pressing a specialized (seat patch) area of the skin to moist surfaces. This behavior, the water absorption response (WR), is preceded by periods of more limited skin contact (seat patch down, SPD) in which the suitability of the rehydration source is evaluated. WR and SPD behaviors were suppressed on 250 mM NaCl and 200 mM KCl solutions. Ten micromolar amiloride partially restored SPD and WR on NaCl solutions. The addition of 5 mM La3+ also partially restored the initiation of WR and this effect was additive to the effect of amiloride, suggesting transcellular and paracellular pathways exist in parallel. Similarly, 5 mM La3+ partially restored the initiation of WR on KCl solutions, to levels comparable to those with K(+)gluconate, suggesting a paracellular pathway for detection of K+. Hyperosmotic (250 mM) NaCl solutions bathing the mucosal surface rapidly and reversibly increased the paracellular conductance of isolated skin and this increase was partially inhibited by 5 mM La3+. These results suggest that the regulation of tight junctions has a chemosensory role in toad skin.
机译：脱水蟾蜍通过将皮肤的特定区域（座垫）压在潮湿的表面上来吸收水分。在这种行为（即吸水响应（WR））之前，会出现皮肤接触更为有限的时期（座垫下降，SPD），在此期间评估补液来源的适用性。在250 mM NaCl和200 mM KCl溶液中，WR和SPD行为受到抑制。十微摩尔阿米洛利在NaCl溶液中部分还原了SPD和WR。 5 mM La3 +的添加也部分恢复了WR的启动，并且这种作用与阿米洛利的作用相加，表明跨细胞途径和旁细胞途径并行存在。同样，5 mM La3 +可以部分恢复KCl溶液中WR的起始，达到与葡萄糖酸K（+）相当的水平，这表明检测K +的细胞旁途径。高渗（250 mM）NaCl溶液迅速并可逆地浸入粘膜表面，增加了离体皮肤的细胞旁电导，而这种增加受到5 mM La3 +的部分抑制。这些结果表明紧密连接的调节在蟾蜍皮肤中具有化学感应作用。

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