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首页> 外文期刊>Paediatric anaesthesia >Efficacy of bupivacaine-neostigmine and bupivacaine-tramadol in caudal block in pediatric inguinal herniorrhaphy.
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Efficacy of bupivacaine-neostigmine and bupivacaine-tramadol in caudal block in pediatric inguinal herniorrhaphy.

机译：布比卡因-新斯的明和布比卡因-曲马多在小儿腹股沟疝的尾状阻滞中的疗效。

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BACKGROUND: Limited duration of analgesia is among the limitations of single caudal injection with local anesthetics. Therefore, the purpose of this study was to evaluate the effectiveness and safety of bupivacaine in combination with either neostigmine or tramadol for caudal block in children undergoing inguinal herniorrhaphy. METHODS: In a double-blinded randomized trial, sixty children undergoing inguinal herniorrhaphy were enrolled to receive a caudal block with either 0.25% bupivacaine (1 ml x kg(-1)) with neostigmine (2 microg x kg(-1)) (group BN) or tramadol (1 mg x kg(-1)) (group BT). Hemodynamic variables, pain and sedation scores, additional analgesic requirements, and side effects were compared between two groups. RESULTS: Duration of analgesia was longer in group BT (17.30 +/- 8.24 h) compared with group BN (13.98 +/- 10.03 h) (P = 0.03). Total consumption of rescue analgesic was significantly lower in group BT compared with group BN (P = 0.04). There were no significant differences in heart rate, mean arterial pressure, and oxygen saturation between groups. Adverse effects excluding the vomiting were not observed in any patients. CONCLUSION: In conclusion, tramadol (1 mg x kg(-1)) compared with neostigmine (2 microg x kg(-1)) might provide both prolonged duration of analgesia and extended time to first analgesic in caudal block.
机译：背景：有限的镇痛持续时间是局部麻醉药单尾注入的局限性。因此，本研究的目的是评估布比卡因与新斯的明或曲马多联合治疗腹股沟疝的儿童的尾椎阻滞的有效性和安全性。方法：在一项双盲随机试验中，入组60名腹股沟腹股沟疝气患儿，接受含有0.25％布比卡因（1 ml x kg（-1））和新斯的明（2 microg x kg（-1））的尾椎阻滞（ BN组）或曲马多（1 mg x kg（-1））（BT组）。比较两组的血液动力学变量，疼痛和镇静分数，其他镇痛要求以及副作用。结果：与BN组（13.98 +/- 10.03 h）相比，BT组（17.30 +/- 8.24 h）镇痛时间更长（P = 0.03）。与BN组相比，BT组的抢救性镇痛剂总消耗量显着降低（P = 0.04）。两组之间的心率，平均动脉压和血氧饱和度无显着差异。在任何患者中均未观察到不良反应，包括呕吐。结论：总的来说，曲马多（1 mg x kg（-1））与新斯的明（2 microg x kg（-1））相比，可能会延长镇痛时间，并延长尾巴首次镇痛的时间。

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