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首页> 外文期刊>Plasmid: An International Journal Devoted to Extrachromosomal Gene Systems >New insights in the role of HtdA in the regulation of R27 conjugation
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New insights in the role of HtdA in the regulation of R27 conjugation

机译：HtdA在调节R27偶联中的作用的新见解

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摘要

R27 is the prototype of the IncHI group of conjugative plasmids, which are associated with multidrug resistance in several relevant pathogens. The transfer of this plasmid is thermodependent and all transfer-related genes are encoded in six operons (tra operons). Very little is known about the factors involved in the regulation of the R27 conjugation. This report describes transcriptional studies of the six tra operons. Our results indicate that HtdA, encoded in the R27 plasmid, is involved in the transcriptional repression of four tra operons (F, H, AC and Z). Although HtdA plays a pivotal role in the transcriptional regulation of those operons, it does not exert its effect as a classical repressor. The data indicate the existence of a crosstalk between HtdA and other unknown regulatory factors. The HtdA-mediated regulation of conjugation is independent of the R27 H-NS protein.
机译：R27是结合质粒的IncHI组的原型，该质粒与几种相关病原体的多药耐药性有关。该质粒的转移是热依赖性的，所有与转移相关的基因都编码在六个操纵子中（tra操纵子）。关于调节R27缀合的因素知之甚少。本报告介绍了六个tra操纵子的转录研究。我们的结果表明，在R27质粒中编码的HtdA参与了四个tra操纵子（F，H，AC和Z）的转录抑制。尽管HtdA在这些操纵子的转录调控中起着关键作用，但它并未发挥其作为经典阻遏物的作用。数据表明HtdA与其他未知调节因子之间存在串扰。 HtdA介导的结合调节独立于R27 H-NS蛋白。

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