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首页> 外文期刊>Paediatric anaesthesia >Protective effect of esmolol on myocardial ischemic injury during open heart surgery in children.
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Protective effect of esmolol on myocardial ischemic injury during open heart surgery in children.

机译：艾司洛尔对儿童心脏直视手术中心肌缺血的保护作用。

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To investigate the efficacy of esmolol in protecting the myocardium from ischemia during pediatric cardiac surgery.Esmolol, an ultra-short acting beta 1-adrenoceptor blocker, reduces myocardial injury in adult cardiac operations. However, this technique is rarely used in pediatric cardiac surgery.Thirty children with ventricular septal defect were randomly allocated to the esmolol group and the control group. Patients received intravenous esmolol (0.05?mg·kg(-1) ·min(-1) after tracheal intubation, 0.3 mg·kg(-1) ·min(-1) during cardiopulmonary bypass (CPB) and 0.03-0.05 mg·kg(-1) ·min(-1) until the end of surgery) or placebo, respectively.Plasma levels of creatine kinase-MB, cardiac troponin I in the esmolol group 2 min after completion of CPB, at the end of surgery, 4?h after surgery, and the first postoperative day were significantly lower than those in the control group. Values of heart rate 10?min after induction, 2?min before institution of CPB, 2?min after completion of CPB, and at the end of surgery were significantly lower in the esmolol group; however, mean arterial pressure, CPB time, cross-clamp time, and the rate of heart spontaneous rebeating were not statistically different between two groups. Cumulative postoperative dosage of dopamine in the esmolol group (100.1?±?53.1?mg) was significantly less than that in the control group (171.4?±?92.1?mg).Esmolol can protect the myocardium from ischemic injury during CPB in children and significantly reduce the use of inotropic drug.
机译：研究艾司洛尔在小儿心脏外科手术中保护心肌免受局部缺血的功效。艾司洛尔是一种超短效β1肾上腺素受体阻滞剂，可减少成人心脏手术中的心肌损伤。然而，这种技术在儿科心脏手术中很少使用。将30例室间隔缺损的儿童随机分为艾司洛尔组和对照组。气管插管后患者接受艾司洛尔静脉注射（0.05？mg·kg（-1）·min（-1），体外循环（CPB）期间接受0.3 mg·kg（-1）·min（-1）和0.03-0.05 mg·每次手术结束后2分钟，艾司洛尔组的肌酸激酶-MB，心肌肌钙蛋白I的血浆水平分别为kg（-1）·min（-1）（直到手术结束）或安慰剂。术后4h，术后第一天明显低于对照组。艾司洛尔组在诱导后10分钟，CPB手术前2分钟，CPB完成后2分钟和手术结束时的心率值均显着降低。但是，两组的平均动脉压，CPB时间，交叉钳夹时间和心脏自发性心跳率在统计学上没有差异。艾司洛尔组的术后多巴胺累积量（100.1±±53.1？mg）显着低于对照组（171.4？±？92.1？mg）。艾司洛尔可以保护儿童免受CPB期间心肌缺血的伤害，大大减少了正性肌力药的使用。

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