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首页> 外文期刊>Paediatric and perinatal epidemiology >Construction and characterisation of a longitudinal clinical blood pressure database for epidemiological studies of hypertension in pregnancy.
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Construction and characterisation of a longitudinal clinical blood pressure database for epidemiological studies of hypertension in pregnancy.

机译：纵向临床血压数据库的构建和表征，用于妊娠高血压病的流行病学研究。

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摘要

Blood pressure measurement plays a central role in the screening and management of hypertension during pregnancy. Although descriptions of changes in blood pressure patterns of normotensive and hypertensive pregnancies are plentiful, relatively little is known about how modifiable environmental and lifestyle characteristics, including maternal diet and physical activity, influence blood pressure levels in pregnancy. In this paper we provide a detailed description of the first 2000 subjects enrolled in the Omega Prospective Cohort Study. Our intention is to characterise the cohort and to establish a rigorous data framework that will form the basis for future analyses of the association between blood pressure patterns in pregnancy and modifiable risk factors. We describe the construction of a representative longitudinal blood pressure analysis database drawn from routinely collected measurements. In doing this, we explore possible over- and under-representation of patients and evaluate ways of modifying the database to address areas of possible bias. In addition, we consider questions of data quality which are specific to blood pressure measurements. In an accompanying paper, we use this database to explore the influence of maternal pre-pregnancy adiposity on blood pressure levels across gestation.
机译：血压测量在妊娠期高血压的筛查和管理中起着核心作用。尽管对血压正常和高血压孕妇的血压模式变化的描述很多，但对可改变的环境和生活方式特征（包括孕妇的饮食和身体活动）如何影响怀孕的血压水平知之甚少。在本文中，我们详细介绍了参与Omega前瞻性队列研究的前2000名受试者。我们的目的是表征队列并建立一个严格的数据框架，该框架将为将来分析妊娠血压模式与可改变的危险因素之间的关联奠定基础。我们描述了从常规收集的测量中得出的代表性纵向血压分析数据库的构建。在此过程中，我们探索了可能出现的患者代表人数过多和不足的情况，并评估了修改数据库以解决可能存在的偏见的方法。此外，我们考虑了特定于血压测量的数据质量问题。在随附的论文中，我们使用该数据库来探索孕妇妊娠前肥胖对整个妊娠期血压水平的影响。

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