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首页> 外文期刊>Plasmid: An International Journal Devoted to Extrachromosomal Gene Systems >Mycoplasma arthritidis bacteriophage MAV1 prophage integration, deletions, and strain-related polymorphisms.
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Mycoplasma arthritidis bacteriophage MAV1 prophage integration, deletions, and strain-related polymorphisms.

机译：支原体噬菌体MAV1噬菌体整合，缺失和菌株相关的多态性。

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摘要

Temperate bacteriophage MAV1 is found in certain highly virulent strains of Mycoplasma arthritidis. Integration sites, portions of the right and left prophage ends, and flanking DNA from eight prophages in seven M. arthritidis strains were characterized in this study. attb and attp sites conformed for the most part to the consensus sequence TATTTTT, although minor polymorphisms were noted. Prophages were integrated into similar sites in four strains, suggesting that these strains may have had a common ancestor. Two strains had three prophage copies each, and integration sites were identical. Two strains had two copies each. One of these shared two of the integration sites occupied in the three-copy strains, while the other shared one of these sites and harbored a second prophage in a unique site. Integration sites in the two strains with one prophage each were unique. Four MAV1 copies contained extensive substitutions within a region encoding a putative structural protein and the putative repressor protein. A 3-kb fragment was deleted from the right side of two of these copies. It is proposed that polymorphisms within MAV1 prophage integration sites and within the prophages themselves may help to identify phylogenetic relationships among virulent M. arthritidis strains.
机译：在某些高度毒性的支原体支原体菌株中发现了温带噬菌体MAV1。这项研究的特点是整合位点，左，左proph末端的部分，以及来自七个M. arthritidis菌株中八个proh的侧翼DNA。 attb和attp位点大部分符合共有序列TATTTTT，尽管发现了较小的多态性。噬菌体被整合到四个菌株的相似位点，表明这些菌株可能具有共同的祖先。两个菌株各具有三个原噬菌体拷贝，并且整合位点相同。两个菌株各有两个副本。其中一个共享了三个拷贝菌株中的两个整合位点，另一个共享了这些位点中的一个，并在一个独特的位点中容纳了第二个噬菌体。在两个菌株中每个都有一个噬菌体的整合位点是独特的。在编码推定的结构蛋白和推定的阻遏蛋白的区域内，四个MAV1拷贝包含大量取代。从其中两个副本的右侧删除了一个3 kb的片段。建议在MAV1噬菌体整合位点内和在噬菌体本身内的多态性可能有助于鉴定强毒的M. arthritidis菌株之间的系统发育关系。

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