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首页> 外文期刊>Paediatric and perinatal epidemiology >Relationships between air pollution and preterm birth in California.
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Relationships between air pollution and preterm birth in California.

机译：加利福尼亚州空气污染与早产之间的关系。

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Air pollution from vehicular emissions and other combustion sources is related to cardiovascular and respiratory outcomes. However, few studies have investigated the relationship between air pollution and preterm birth, a primary cause of infant mortality and morbidity. This analysis examined the effect of fine particulate matter (PM(2.5)) and carbon monoxide (CO) on preterm birth in a matched case-control study. PM(2.5) and CO monitoring data from the California Air Resources Board were linked to California birth certificate data for singletons born in 1999-2000. Each birth was mapped to the closest PM monitor within 5 miles of the home address. County-level CO measures were utilised to increase sample size and maintain a representative population. After exclusion of implausible birthweight-gestation combinations, preterm birth was defined as birth occurring between 24 and 36 weeks' gestation. Each of the 10 673 preterm cases was matched to three controls of term (39-44 weeks) gestation with a similardate of last menstrual period. Based on the case's gestational age, CO and PM(2.5) exposures were calculated for total pregnancy, first month of pregnancy, and last 2 weeks of pregnancy. Exposures were divided into quartiles; the lowest quartile was the reference. Because of the matched design, conditional logistic regression was used to adjust for maternal race/ethnicity, age, parity, marital status and education. High total pregnancy PM(2.5) exposure was associated with a small effect on preterm birth, after adjustment for maternal factors (adjusted odds ratio [AOR] = 1.15, [95% CI 1.07, 1.24]). The odds ratio did not change after adjustment for CO. Results were similar for PM(2.5) exposure during the first month of pregnancy (AOR = 1.21, 95% CI [1.12, 1.30]) and the last 2 weeks of pregnancy (AOR = 1.17, 95% CI [1.09, 1.27]). Conversely, CO exposure at any time during pregnancy was not associated with preterm birth (AORs from 0.95 to 1.00). Maternal exposure to PM(2.5), but not CO, is associated with preterm birth. This analysis did not show differences by timing of exposure, although more detailed examination may be needed.
机译：车辆排放和其他燃烧源造成的空气污染与心血管和呼吸系统的后果有关。但是，很少有研究调查空气污染与早产之间的关系，早产是婴儿死亡率和发病率的主要原因。在一项匹配的病例对照研究中，该分析检查了细颗粒物（PM（2.5））和一氧化碳（CO）对早产的影响。来自加州空气资源委员会的PM（2.5）和CO监测数据与1999-2000年出生的单身人士的加利福尼亚出生证明数据相关联。每次出生都映射到家庭住址5英里内最近的PM监视器。利用县级的CO措施来增加样本量并维持代表性人口。排除不合理的体重妊娠组合后，早产定义为发生在妊娠24至36周之间的婴儿。 10 673例早产病例中的每一个均与足月妊娠（39-44周）的三个对照相匹配，且最后一次月经的日期相似。根据病例的胎龄，计算出总妊娠，妊娠第一个月和妊娠最后2周的CO和PM（2.5）暴露。曝光分为四分位数;最低的四分位数是参考。由于采用了匹配的设计，因此有条件的逻辑回归用于调整孕妇的种族/民族，年龄，均等，婚姻状况和受教育程度。在调整了孕产妇因素后，高总妊娠PM（2.5）暴露与对早产的影响很小（调整后的优势比[AOR] = 1.15，[95％CI 1.07，1.24]）。校正CO后，优势比没有变化。怀孕第一个月（AOR = 1.21，95％CI [1.12，1.30]）和怀孕最后两周（AOR = 1.17，95％CI [1.09，1.27]。相反，怀孕期间任何时候的一氧化碳暴露都与早产无关（AOR为0.95至1.00）。孕妇暴露于PM（2.5）而不是CO与早产有关。尽管可能需要更详细的检查，但该分析并未显示出暴露时间的差异。

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