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首页> 外文期刊>Plasmid: An International Journal Devoted to Extrachromosomal Gene Systems >Comparative overview of the genomic and genetic differences between the pathogenic Neisseria strains and species.
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Comparative overview of the genomic and genetic differences between the pathogenic Neisseria strains and species.

机译：致病性奈瑟氏菌菌株和物种之间的基因组和遗传差异的比较概述。

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摘要

The availability of complete genome sequences from multiple pathogenic Neisseria strains and species has enabled a comprehensive survey of the genomic and genetic differences occurring within these species. In this review, we describe the chromosomal rearrangements that have occurred, and the genomic islands and prophages that have been identified in the various genomes. We also describe instances where specific genes are present or absent, other instances where specific genes have been inactivated, and situations where there is variation in the version of a gene that is present. We also provide an overview of mosaic genes present in these genomes, and describe the variation systems that allow the expression of particular genes to be switched ON or OFF. We have also described the presence and location of mobile non-coding elements in the various genomes. Finally, we have reviewed the incidence and properties of various extra-chromosomal elements found within these species. The overall impression is oneof genomic variability and instability, resulting in increased functional flexibility within these species.
机译：来自多种致病性奈瑟氏菌菌株和物种的完整基因组序列的可用性，使得能够对这些物种内发生的基因组和遗传差异进行全面调查。在这篇综述中，我们描述了已经发生的染色体重排，以及在各种基因组中已经鉴定出的基因组岛和原噬菌体。我们还描述了存在或不存在特定基因的情况，已灭活特定基因的其他情况，以及存在的基因版本存在差异的情况。我们还提供了这些基因组中存在的镶嵌基因的概述，并描述了允许将特定基因的表达打开或关闭的变异系统。我们还描述了各种基因组中移动非编码元件的存在和位置。最后，我们回顾了在这些物种中发现的各种染色体外元素的发生率和特性。总体印象是基因组变异性和不稳定性之一，导致这些物种内功能的灵活性增加。

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