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首页> 外文期刊>Plasmid: An International Journal Devoted to Extrachromosomal Gene Systems >Induction of pCW3-encoded tetracycline resistance in Clostridium perfringens involves a host-encoded factor.
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Induction of pCW3-encoded tetracycline resistance in Clostridium perfringens involves a host-encoded factor.

机译：产气荚膜梭菌中pCW3编码的四环素抗性的诱导涉及宿主编码因子。

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摘要

The tetracycline resistance determinant Tet P, which is encoded by the conjugative plasmid pCW3 from Clostridium perfringens, is induced by subinhibitory concentrations of tetracycline. In this study we have shown that the inducible phenotype is strain dependent. When pCW3 is present in derivatives of the wild-type strains CW234 and CW362 resistance is inducible. However, transfer to derivatives of strain 13 leads to a constitutive phenotype that is only observed in this strain background. Based on these results it is proposed that induction of the pCW3-encoded tet(P) genes in C. perfringens requires a host-encoded factor that is either absent or nonfunctional in strain 13 derivatives.
机译：由来自产气荚膜梭菌的结合质粒pCW3编码的四环素抗性决定簇Tet P是由亚抑制浓度的四环素诱导的。在这项研究中，我们已经表明，诱导型是依赖菌株的。当野生型菌株CW234和CW362的衍生物中存在pCW3时，可诱导抗性。然而，转移至菌株13的衍生物导致仅在该菌株背景中观察到的组成型表型。基于这些结果，提出在产气荚膜梭菌中pCW3编码的tet（P）基因的诱导需要在菌株13衍生物中不存在或不起作用的宿主编码因子。

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