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Expression of T1Rs and Gustducin in Palatal Taste Buds of Mice

机译：T1Rs和Gustducin在小鼠Pala味芽中的表达

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摘要

The palatal region of the oral cavity in rodents houses 100-300 taste buds and is particularly sensitive to sweet and umami compounds;yet,few studies have examined the expression patterns of transduction-related molecules in this taste field.We investigated the interrelationships between members of the T1R family and between each T1R and gustducin in palatal taste buds.Similar to lingual taste buds,T1R1 and T1R2 are generally expressed in separate palatal taste cells.In contrast to lingual taste buds,however,T1R2 and T1 R3-positive palatal taste cells almost always coexpress gustducin,suggesting that sweet taste transduction in the palate is almost entirely dependent on gustducin.T1R1-positive palate taste cells coexpress gustducin about half the time,suggesting that other G proteins may contribute to the transduction of umami stimuli in this taste field.
机译：啮齿类动物的口腔上颚区域可容纳100-300个味蕾，并且对甜味和鲜味化合物特别敏感;然而，很少有研究检查该味觉领域中与转导相关的分子的表达方式。我们研究了成员之间的相互关系在舌taste味蕾中，T1R1和T1R2与舌味蕾相似，通常在单独的pa味细胞中表达。与舌味味蕾相反，T1R2和T1 R3阳性pa味T1R1阳性味觉细胞共表达gustducin约一半时间，暗示其他G蛋白可能有助于味觉刺激的转导，T1R1阳性味觉细胞几乎总是与gustducin共表达。领域。

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