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首页> 外文期刊>Chemical Senses >Putative Chemical Signals about Sex,Individuality,and Genetic Background in the Preputial Gland and Urine of the House Mouse(Mus musculus)
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Putative Chemical Signals about Sex,Individuality,and Genetic Background in the Preputial Gland and Urine of the House Mouse(Mus musculus)

机译：关于家鼠（小家鼠）的前腺和尿液中的性别，个体和遗传背景的假定化学信号

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To explore whether preputial gland secretions and/or urine from the house mouse(Mus musculus)can be used for coding information about sex,individuality,and/or the genetic background of strain[ICR/albino,Kunming(KM),and C57BL/6],we com pared the volatile compositions of mouse preputial glands and urine using a combination of dichloromethane extraction and gas chromatography coupled with mass spectrometry(GC-MS).Of the 40 identified compounds in preputial gland secretions,31 were esters,2 sesquiterpens,and 7 alcohols.We failed to find any compound unique to a specific sex,individual,or strain.However,many low molecular weight compounds between the sexes,most compounds among individuals,and several com pounds among the 3 strains varied significantly in relative ratios.These quantitative differences in preputial gland volatiles(analog coding)are likely to convey information about sex,individual,and the genetic background of mouse strain.We identified 2 new main and male-elevated compounds,1-hexadecanol(Z=3.676,P=0.000,N=19 in ICR;Z=3.576,P=0.000,N=18)and 1-hexadecanol acetate(Z=3.429,P=0.000,N=19 in ICR;Z=3.225,P=0.001,N=18),which were eluted in GC chromato-gram after the 2 sesquiterpens.They might also be potential male pheromones,in addition to the well-known 5-beta-farnesene and E,E-alpha-farnesene.Additionally,a few compounds including 1-hexadecanol also varied with strains and might also code for genetic information.Of the 9 identified volatile compounds in male urine,(s)-2-sec-butyl-4,5-dihydrothiazole and R,R-3,4-dehydro-exo-brevicomin are known urine-originated male pheromones from previous studies.We also detected 6-hydroxy-6-methyl-3-heptanone,a male urinary pheromonal compound,which had not been directly detected by GC-MS previously.Chemical analysis shows that the genetically more closely related ICR and KM strains had a higher similarity in the volatile compositions of preputial glands and urine than that between ICR or KM and C57BL/6.R,R-3,4-dehydro-exo-brevicomin,in particular,was sensitive to genetic shifts and differed in relative abundance among the 3 strains,whereas(s)-2-sec-butyl-4,5-dihydrothiazole differed between ICR or Km and C57BL/6.Hence,these 2 compounds might code for information about their genetic background.
机译：要探索家鼠（小家鼠）的前腺分泌物和/或尿液是否可用于编码有关菌株的性别，个性和/或遗传背景的信息[ICR / albino，Kunming（KM）和C57BL / [6]，采用二氯甲烷萃取-气相色谱-质谱联用（GC-MS），比较了小鼠前腺和尿液的挥发性成分。在前腺分泌物中鉴定出的40种化合物中，酯类，倍半萜类为31种。 ，以及7种醇。我们未能找到特定性别，个体或菌株所特有的任何化合物。但是，性别之间的许多低分子量化合物，个体之间的大多数化合物以及3株菌株中的几种化合物相对而言差异显着这些皮脂腺挥发物的定量差异（模拟编码）可能传达有关小鼠品系的性别，个体和遗传背景的信息。我们确定了2种新的主要和雄性升高的化合物， ICR中的1-十六烷醇（Z = 3.676，P = 0.000，N = 19; ICR中的Z = 3.576，P = 0.000，N = 18）和1-十六烷醇乙酸酯（Z = 3.429，P = 0.000，N = 19; Z = 3.225，P = 0.001，N = 18），在2次倍半萜后用GC色谱法洗脱。除众所周知的5-β-法呢烯和E，E外，它们还可能是潜在的雄性信息素。 -α-法呢烯。此外，包括1-十六烷醇在内的一些化合物也随菌株而变化，并且可能还编码遗传信息。在男性尿液中鉴定出的9种挥发性化合物中，（s）-2-sec-butyl-4,5-二氢噻唑和R，R-3,4-dehydro-exo-brevicomin是先前研究中已知的尿源性雄性信息素。我们还检测到6-羟基-6-甲基-3-庚酮，一种雄性尿液信息素，没有化学分析表明，与遗传密切相关的ICR和KM菌株在包皮腺和尿液的挥发性成分中具有比在ICR或KM与C57BL / 6.R，R-之间更高的相似性。 3,4-脱氢exo-br特别是evicomin，对3种菌株的遗传变化敏感，相对丰度也不同，而ICR或Km与C57BL / 6之间的-2-仲丁基-4,5-二氢噻唑不同，因此这2种这些化合物可能会编码有关其遗传背景的信息。

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