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首页> 外文期刊>Preparative biochemistry & biotechnology: An international journal for rapid communication >Effect of synthetic oligopeptides on osteoporosis
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Effect of synthetic oligopeptides on osteoporosis

机译：合成寡肽对骨质疏松症的作用

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The objective of this study was to establish the solution method of GHRPS, the synthetic oligopeptides Tyr-Gly-Gly-Phe-Met-NH_2, Tyr-Gly-Gly- Phe-Met-OH, Tyr-Gly-Gly-Phe-Leu-NH_2, Tyr-Gly-Gly-Phe-Leu-OH, Tyr-Gly-Gly-Phe-Gly-NH_2, and Tyr-Gly-Gly-Phe-Gly-OH, to verify their effect on osteoporosis. Male ICR mice (20 +- 2 g) were used. The intramuscular injection dose of 6.3 mg/kg prednisone induced a significant decrease of body and femur weight of the animals. The subcutaneous injection dose of 18 mug/kg synthetic peptide was not effective to prevent the decrease of body and femur weight of the animals. The subcutaneous injection does of 6.3 mg/kg prednisone elicited a decrease in content of femur calcium and in the level of serum calcium of the animals. The subcutaneous injection dose of 18 mug/kg Tyr-Gly-Gly-Phe-Leu-NH_2, or Tyr-Gly-Gly-Phe-Leu-OH, or Tyr-Gly-Gly-Phe-Gly-NH_2 significantly increased the content of femur calcium and decreased the level of serum calcium of the animals. It was also observed that the subcutaneous injection dose of 18 mug/kg Tyr-Gly-Gly-Phe-Gly-OH, Tyr-Gly-Gly-Phe-Leu-OH, Tyr-Gly-Gly-Phe-Met-OH, Tyr-Gly-Gly-Phe-Met-NH_2 significantly increased the content of femur phosphorous and decreased the activity of ALP of the animals.
机译：这项研究的目的是建立GHRPS的解决方法，合成的寡肽Tyr-Gly-Gly-Phe-Met-NH_2，Tyr-Gly-Gly-Phe-Met-OH，Tyr-Gly-Gly-Phe-Leu -NH_2，Tyr-Gly-Gly-Phe-Leu-OH，Tyr-Gly-Gly-Phe-Gly-NH_2和Tyr-Gly-Gly-Phe-Gly-OH，以验证它们对骨质疏松症的作用。使用雄性ICR小鼠（20±2g）。肌肉注射剂量泼尼松6.3 mg / kg导致动物的体重和股骨重量显着降低。皮下注射剂量为18马克/千克的合成肽对防止动物的体重和股骨重量的减少是无效的。 6.3 mg / kg泼尼松的皮下注射引起动物股骨钙含量和血清钙水平的降低。皮下注射剂量为18杯/ kg Tyr-Gly-Gly-Phe-Leu-NH_2或Tyr-Gly-Gly-Phe-Leu-OH或Tyr-Gly-Gly-Phe-Gly-NH_2降低股骨钙，降低动物的血清钙水平。还观察到皮下注射剂量为18杯/ kg Tyr-Gly-Gly-Phe-Gly-OH，Tyr-Gly-Gly-Phe-Leu-OH，Tyr-Gly-Gly-Phe-Met-OH， Tyr-Gly-Gly-Phe-Met-NH_2显着增加了股骨磷的含量，并降低了动物的ALP活性。

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