One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones using CuBr_2 as Catalyst

Haixia Zhou; Miao He; Chunsheng Liu

首页> 外文期刊>Preparative biochemistry & biotechnology: An international journal for rapid communication >One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones using CuBr_2 as Catalyst

【24h】

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones using CuBr_2 as Catalyst

机译：以CuBr_2为催化剂一锅法合成3,4-二氢嘧啶-2（1H）-一

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A simple,efficient procedure and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives.This synthesis was performed using CuBr_2 as the catalyst in ethanol solution.The optimum conditions were as follows: the molar ratio of aldehyde to alpha,beta-diketone to urea or thiourea is 1:1:1:0.5,the molar ratio of catalyst to aldehyde is 25%,and the reaction time is 4 h.Under the above conditions,the highest yield of dihydropyrimidinones was up to 95%.Compared with the classical Biginelli reaction conditions,this new method has the advantage of excellent yields and short reaction times.

机译：发现了一种简单，有效的方法和改进的条件，可进行Biginelli反应合成3,4-二氢嘧啶-2（1H）-one衍生物。以CuBr_2为催化剂在乙醇溶液中进行合成。条件为：醛与α，β-二酮与尿素或硫脲的摩尔比为1：1：1：0.5，催化剂与醛的摩尔比为25％，反应时间为4 h。在上述条件下，二氢嘧啶酮的最高收率可达95％。与经典的Biginelli反应条件相比，该新方法具有收率高，反应时间短的优点。

著录项

来源
《Preparative biochemistry & biotechnology: An international journal for rapid communication》 |2006年第4期|共7页
作者
Haixia Zhou; Miao He; Chunsheng Liu;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
CuBr_2; Catalyst; Biginelli reaction; Dihydropyrimidinones; One-pot; Synthesis;

机译：CuBr_2;催化剂;Biginelli反应;二氢嘧啶酮;一锅法;合成;

相似文献

外文文献
中文文献
专利

1. One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones using CuBr_2 as Catalyst [J] . Haixia Zhou, Miao He, Chunsheng Liu Preparative biochemistry & biotechnology: An international journal for rapid communication . 2006,第4期

机译：以CuBr_2为催化剂一锅法合成3,4-二氢嘧啶-2（1H）-一
2. One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts [J] . Genxiang Luo Chunsheng Liu Haixia Zhou Miao He Letters in Organic Chemistry . 2006,第3期

机译：盐酸-β-环糊精结合催化剂一锅法合成3,4-二氢嘧啶-2（1H）-一
3. One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using hydrochloric acid-beta-cyclodextrin-combined catalysts [J] . Zhou HX, He M, Liu CS, Letters in organic chemistry . 2006,第3期

机译：使用盐酸-β-环糊精结合催化剂一锅法合成3,4-二氢嘧啶-2（1H）-一
4. ONE-POT MULTICOMPONENT SYNTHESIS of 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES USING SILICA-SUPPORTED PREYSSLER NANOPARTICLES AS A NOVEL, ECO-FRIENDLY and GREEN CATALYST [C] . Fatemeh F. Bamoharram, Majid M. Heravi, Mina Roshani, 6th international conference on environmental catalysis : Abstract book . 2010

机译：一键多组分合成3,4-二氢吡啶酮N-2（1H）-使用二氧化硅支撑的PreySSLer纳米粒子作为新型，环保和绿色催化剂
5. New developments toward the synthesis of heterocycles and applications in green chemistry. I. A simple and essentially one-pot synthesis of N-aminated heterocycles using phase transfer catalyst (Aliquat-336). II. Synthesis of pharmaceutically important pyrrole derivatives. III. Applications in green chemistry: Surfactant-mediated environmentally friendly cleavage of aromatic esters and trans-esterification under solvent-free neutral conditions . [D] . Patel, Nitinchandra. 2005

机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
6. A Green Expeditious One-Pot Synthesis of 3 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature [O] . Amulrao Borse, Mahesh Patil, Nilesh Patil, 2012

机译：在环境温度下使用五氧化二磷-甲磺酸混合物进行绿色快速的一锅合成34-Dihydropyrimidin-2（1H）-ones
7. An Efficient One-Pot Protocol for the Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones Using Metallophthalocyanines (MPcs) as Potent Heterogeneous Catalysts: Synthesis, Characterization, Aggregation and Antimicrobial Activity [O] . Naceur Hamdi, Rawdha Medyouni, Hallouma Bilel, 2017

机译：使用金属酞菁（mpcs）作为有效多相催化剂合成取代的3,4-二氢嘧啶-2（1H） - 酮的高效一锅法：合成，表征，聚集和抗菌活性

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones using CuBr_2 as Catalyst

摘要

著录项

相似文献

相关主题

期刊订阅