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首页> 外文期刊>Peptides: An International Journal >Involvement of cocaine-amphetamine regulated transcript in the differential feeding responses to nociceptin/orphanin FQ in dark agouti and Wistar Ottawa Karlsburg W rats.
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Involvement of cocaine-amphetamine regulated transcript in the differential feeding responses to nociceptin/orphanin FQ in dark agouti and Wistar Ottawa Karlsburg W rats.

机译：可卡因-苯丙胺调节的转录物参与黑暗刺豚鼠和Wistar Ottawa Karlsburg W大鼠对伤害感受肽/孤啡肽FQ的不同摄食反应。

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摘要

Wistar Ottawa Karlsburg W (WOKW) rats and their controls, dark agouti (DA), present different features: in particular, DA rats are lean, while the WOKW are obese and present symptoms of hypertension, dyslipidemia, hyperinsulinemia, and impaired glucose tolerance. The present study tested the hypothesis that these two strains would demonstrate different sensitivity to nociceptin/orphanin FQ (N/OFQ). N/OFQ was injected into the lateral brain ventricle (LBV) of sated DA and WOKW rats, and corticosterone levels in both strains were measured after LBV injection of N/OFQ. LBV N/OFQ injections dose-dependently produced a significant increase in food intake (4 h) in DA rats, but not in WOKW. However, corticosterone levels were increased by N/OFQ to a greater degree in WOKW than in DA rats. Gene sequencing and gene expression of ORL1 receptor and cocaine-amphetamine regulated transcript (Cart) peptide were evaluated to study the difference in N/OFQ-induced feeding behavior in the two strains. WOKW rats had a different amino acid sequence of Cart peptide and a significantly higher expression of Cart in the hypothalamus. The present data show that DA and WOKW rats demonstrate different sensitivity to N/OFQ, and suggest that Cart peptide might be the underlying mechanism of this difference.
机译：Wistar渥太华Karlsburg W（WOKW）大鼠及其对照组暗鼠（DA）具有不同的特征：特别是，DA大鼠是瘦型的，而WOKW是肥胖的，并且表现出高血压，血脂异常，高胰岛素血症和葡萄糖耐量降低的症状。本研究检验了以下假设，即这两种菌株将显示出对痛觉敏/孤儿蛋白FQ（N / OFQ）的不同敏感性。将N / OFQ注射到足量DA和WOKW大鼠的大脑侧脑室（LBV）中，并在LBV注射N / OFQ后测量两种品系中的皮质酮水平。 LBV N / OFQ注射剂量依赖性地使DA大鼠的食物摄入量（4小时）显着增加，但WOKW没有。然而，与DA大鼠相比，WOKW中N / OFQ使皮质酮水平升高的程度更大。评估了ORL1受体和可卡因-苯丙胺调节的转录本（Cart）肽的基因测序和基因表达，以研究这两种菌株在N / OFQ诱导的摄食行为上的差异。 WOKW大鼠具有不同的Cart肽氨基酸序列，并且下丘脑中Cart的表达明显较高。目前的数据表明DA和WOKW大鼠对N / OFQ表现出不同的敏感性，并提示Cart肽可能是这种差异的潜在机制。

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