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首页> 外文期刊>Peptides: An International Journal >Effect of carnosine supplementation on apoptosis and irisin, total oxidant and antioxidants levels in the serum, liver and lung tissues in rats exposed to formaldehyde inhalation
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Effect of carnosine supplementation on apoptosis and irisin, total oxidant and antioxidants levels in the serum, liver and lung tissues in rats exposed to formaldehyde inhalation

机译：肌肽补充对吸入甲醛的大鼠血清，肝，肺组织细胞凋亡和虹膜素，总氧化剂和抗氧化剂水平的影响

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The main objective of the study has been to show whether carnosine has positive effects on liver and lung tissues of rats exposed to a range of formaldehyde concentrations, and to explore how irisin expression and antioxidant capacity are altered in these tissues by carnosine supplementation. Sprague-Dawley type male rats were divided into 8 groups with 6 animals in each: (I) Control; no chemical supplementation); (II) sham (100 mg/kg/day carnosine); (III) low dose formaldehyde (LDFA) for 5 days/week; (IV) LDFA for 5 days/week and carnosine); (V) moderate dose formaldehyde (MDFA) for 5 days/week); (VI) MDFA for 5 days/week and carnosine; (VII) high dose formaldehyde (HDFA) for 5 days/week; (VIII) and HDFA for 5 days/week and carnosine. Sham and control groups were exposed to normal air. Irisin levels of the serum, liver and lung tissue supernatants were analyzed by ELISA, while the REL method was used to determine total oxidant/antioxidant capacity. Irisin production by the tissues was detected immunohistochemically. Increasing doses of FA decreased serum/tissue irisin and total antioxidant levels relative to the controls, as also to increases in TUNEL expressions, total oxidant level, oxidant and apoptosis index. Irisin expression was detected in hepatocyte and sinusoidal cells of the liver and parenchymal cells of the lung. In conclusion, while FA exposure reduces irisin and total oxidant in the serum, liver and lung tissues in a dose-dependent manner and increases the total antioxidant capacity, carnosine supplementation reduces the oxidative stress and restores the histopathological and biochemical signs. (C) 2014 Elsevier Inc. All rights reserved.
机译：该研究的主要目的是显示肌肽是否对暴露于一系列甲醛浓度的大鼠的肝和肺组织具有积极作用，并探讨肌肽补充后这些组织中虹膜素表达和抗氧化能力如何改变。将Sprague-Dawley型雄性大鼠分为8组，每组6只。没有化​​学补充）; （II）假（100毫克/千克/天肌肽）; （III）低剂量甲醛（LDFA），为期5天/周; （IV）LDFA /每周5天和肌肽）; （V）5天/周的中剂量甲醛（MDFA）; （VI）每周5天的MDFA和肌肽; （VII）高剂量甲醛（HDFA），连续5天/周; （VIII）和HDFA /每周5天和肌肽。假手术组和对照组均暴露于正常空气中。通过ELISA分析血清，肝和肺组织上清液中鸢尾素的水平，而REL方法用于确定总氧化剂/抗氧化剂的能力。免疫组织化学检测组织的鸢尾素产生。相对于对照，增加的FA剂量降低了血清/组织虹膜素和总抗氧化剂水平，还增加了TUNEL表达，总氧化剂水平，氧化剂和细胞凋亡指数。在肝脏的肝细胞和肝窦细胞以及肺的实质细胞中检测到了鸢尾素的表达。总而言之，尽管暴露于FA会以剂量依赖的方式减少血清，肝和肺组织中的虹膜素和总氧化剂，并增加总抗氧化能力，但肌肽的补充降低了氧化应激并恢复了组织病理学和生化指标。 （C）2014 Elsevier Inc.保留所有权利。

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