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Advances in platelet function testing assessing bleeding complications in patients with coronary artery disease

机译：血小板功能检测评估冠心病患者出血并发症的研究进展

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摘要

Antiplatelet therapy is the cornerstone of treatment in preventing ischemic events in patients with coronary artery disease (CAD), particularly in the setting of acute coronary syndromes and percutaneous coronary interventions. However, antiplatelet therapy is also associated with an increased risk of bleeding complications, which are more frequent with the use of more potent antiplatelet treatment regimens. Therefore, defining the balance between the risk of thrombotic events and the risk of bleeding is essential to improve overall clinical outcomes. The pharmcodynamic effects of antiplatelet agents vary broadly and may be associated with differences in outcomes. In particular, patients are at an increased risk of ischemic or bleeding complications if the pharmacodynamic effects are reduced or enhanced, respectively. Multiple platelet function assays are currently available to assess the pharmacodynamic effects of commonly used antiplatelet agents. The present manuscript will review the prognostic value of platelet function testing to identify patients with CAD at risk of bleeding complications and the potential applications of these tests in the modern era of antiplatelet pharmacotherapy.
机译：抗血小板疗法是预防冠心病（CAD）患者缺血事件的治疗基石，尤其是在急性冠脉综合征和经皮冠状动脉介入治疗中。然而，抗血小板治疗也与出血并发症风险增加有关，出血并发症的发生率随着使用更有效的抗血小板治疗方案而更加频繁。因此，定义血栓形成事件的风险与出血风险之间的平衡对于改善整体临床结局至关重要。抗血小板药的药效学作用差异很大，可能与结果的差异有关。特别地，如果分别降低或增强药效作用，则患者处于缺血或出血并发症的风险增加。目前有多种血小板功能测定可用于评估常用抗血小板药的药效学作用。本手稿将回顾血小板功能测试的预后价值，以识别具有出血并发症风险的CAD患者，以及这些测试在抗血小板药物治疗的现代时代中的潜在应用。

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