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首页> 外文期刊>Platelets >Development of thrombocytosis in HIV+ drug users: impact of antiretroviral therapy.
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Development of thrombocytosis in HIV+ drug users: impact of antiretroviral therapy.

机译：HIV +吸毒者的血小板增多症发展：抗逆转录病毒疗法的影响。

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With the exception of hemolytic anemia, the potential hematological toxicity of antiretrovirals (ARV) and combination treatments in HIV treated individuals has not been well established. We report, for the first time, hematological toxicity defined as thrombocytosis in 9% of the HIV+ patients receiving highly active antiretroviral treatment (HAART) being followed in a nutritional clinical trial. Participants were evaluated every 6 months during a 2-year period (1998-2000) and blood drawn for biochemical, hematological and immunological parameters. NK cells were negatively correlated with platelet counts in the total cohort (P = 0.018) and persistently elevated with ARVT. Chronic thrombocytosis was associated with significantly lower NK percentages (P = 0.005). Twenty-five percent of the patients with thrombocytosis developed a cardiovascular disease. Together, these results support the proposal that HAART may increase the risk of hematological dysfunction and impact the risk of cardiovascular disease.
机译：除溶血性贫血外，抗逆转录病毒药物（ARV）和联合治疗在HIV感染者中的潜在血液学毒性尚未得到很好的确定。我们首次报告了在营养性临床试验中，血液中毒的定义为接受高活性抗逆转录病毒治疗（HAART）的9％的HIV +患者的血小板毒性。在两年期间（1998-2000年）每6个月对参与者进行一次评估，并抽取血液中的生化，血液和免疫学参数。 NK细胞与总队列中的血小板计数呈负相关（P = 0.018），并且在ARVT中持续升高。慢性血小板增多症与NK百分比明显降低有关（P = 0.005）。 25％的血小板增多症患者患了心血管疾病。总之，这些结果支持了HAART可能增加血液功能障碍风险并影响心血管疾病风险的提议。

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