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首页> 外文期刊>Platelets >Changes in the effects of interleukin-1beta and tumor necrosis factor-alpha on platelet activation in early pregnancy.
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Changes in the effects of interleukin-1beta and tumor necrosis factor-alpha on platelet activation in early pregnancy.

机译：白细胞介素-1β和肿瘤坏死因子-α对妊娠早期血小板活化的影响的变化。

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摘要

Platelets are known to be activated in normal pregnancy, and are further activated in pathological pregnancy states, such as preeclampsia. The factors controlling platelet activation are unknown, but cytokines, such as interleukin 1beta (IL-1beta) and tumor necrosis-alpha (TNF-alpha) have been found to affect platelet function and are believed to be involved in early pregnancy. We assessed the effects of these cytokines on platelets from women at various stages of pregnancy. We compared two methods: platelet in vitro aggregation by aggregometry, and platelet P-selectin expression by flow cytometry. IL-1beta and TNF-alpha had no effect on the in vitro aggregation and P-selectin expression of platelets from women in the first trimester of pregnancy as compared to the inhibitory effects of both in late pregnancy. We conclude that maternal platelet function undergoes a marked change throughout pregnancy.
机译：已知血小板在正常妊娠中被激活，并且在病理性妊娠状态（如先兆子痫）中进一步被激活。控制血小板活化的因素尚不清楚，但已发现细胞因子（如白介素1β（IL-1beta）和肿瘤坏死-α（TNF-α））会影响血小板功能，并被认为与早孕有关。我们评估了这些细胞因子对妊娠各个阶段妇女血小板的影响。我们比较了两种方法：通过凝集测定法进行的血小板体外聚集和通过流式细胞术进行的血小板P-选择蛋白表达。与妊娠晚期两者的抑制作用相比，IL-1β和TNF-α对妊娠早期妇女体内血小板的体外聚集和P选择素表达没有影响。我们得出结论，孕妇的血小板功能在整个怀孕期间都会发生显着变化。

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