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首页> 外文期刊>Platelets >Concomitant spuriously elevated white blood cell count, a previously underestimated phenomenon in EDTA-dependent pseudothrombocytopenia
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Concomitant spuriously elevated white blood cell count, a previously underestimated phenomenon in EDTA-dependent pseudothrombocytopenia

机译：伴随的假性白血球计数升高，这是EDTA依赖性假血小板减少症以前被低估的现象

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The proportion and potential risk of concomitant spuriously elevated white blood cell count (SEWC) are underestimated in ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP). The proportion, kinetics and prevention of SEWC remain poorly understood. A total of 25 patients with EDTA-dependent PTCP were enrolled in this study. With the hematology analyzer Coulter LH 750, we determined the time courses of WBC count, WBC differential and platelet count in EDTA-and sodium citrate-anticoagulated blood, respectively. Blood smears were prepared to inspect the presence of platelet clumps using light microscopy. The effect of automatic instrumental correction on the extent of SEWC was evaluated. The proportion of SEWC was 92% in EDTA-dependent PTCP and 73.9% of SEWCs were within the normal range. The development of SEWC was time-dependent, and neutrophils and lymphocytes were the main subpopulations involved in SEWC. A strong and significant correlation (r = 0.9937, p<0.001) was found between the increased WBC count and the decreased platelet count. Both corrected and uncorrected WBC counts at 15 minutes or later after blood collection in EDTA were significantly higher than their basal counts, respectively, p50.05. Interestingly, in citrated blood, WBC counts after blood collection were not significantly different from its basal counts, p>0.05. A high proportion of concomitant SEWCs, which are mainly within normal range, are present in patients with EDTA-dependent PTCP. Proper interpretation of SEWC is crucial to avoid clinic errors. SEWC develops in a time-dependent pattern, although the Coulter LH 750 only partly mitigates the extent of SEWC, sodium citrate is able to effectively prevent SEWC.
机译：在乙二胺四乙酸（EDTA）依赖性假性血小板减少症（PTCP）中，低估了伴随的伪造白细胞计数（SEWC）的比例和潜在风险。 SEWC的比例，动力学和预防仍然知之甚少。共有25例EDTA依赖性PTCP患者入选本研究。使用血液分析仪Coulter LH 750，我们分别确定了EDTA和柠檬酸钠抗凝血液中WBC计数，WBC差异和血小板计数的时间过程。准备血涂片以使用光学显微镜检查血小板团块的存在。评估了自动仪器校正对SEWC范围的影响。在依赖EDTA的PTCP中SEWC的比例为92％，SEWC的比例为正常范围的73.9％。 SEWC的发展是时间依赖性的，中性粒细胞和淋巴细胞是SEWC的主要亚群。在WBC计数增加和血小板计数减少之间发现强相关性（r = 0.9937，p <0.001）。 EDTA采血后15分钟或更晚，校正后和未校正的WBC计数分别显着高于其基础计数，p50.05。有趣的是，在柠檬酸血液中，采血后的白细胞计数与其基础计数无显着差异，p> 0.05。 EDTA依赖性PTCP患者中存在大量的SEWC，主要在正常范围内。正确解释SEWC对于避免临床错误至关重要。尽管Coulter LH 750仅部分缓解SEWC的程度，但SEWC的发展与时间有关，柠檬酸钠能够有效预防SEWC。

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