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首页> 外文期刊>Platelets >Inhibitory effect of aqueous extracts of some herbs on human platelet aggregation in vitro.
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Inhibitory effect of aqueous extracts of some herbs on human platelet aggregation in vitro.

机译：一些草药的水提取物对人血小板聚集的体外抑制作用。

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Effect of aqueous extract of several herbs on human platelet aggregation in vitro was investigated. Out of 28 herbsutriceuticals investigated, camomile, nettle alfalfa, garlic and onion exhibited most significant anti-platelet activity (>or=45% inhibition). Aqueous extracts of alfalfa, fresh nettle, and camomile inhibited ADP induced-platelet aggregation by 73, 65 and 60%, respectively, compared with control (P < 0.05). Camomile and alfalfa inhibited collagen-induced platelet aggregation by 84 and 65%, respectively, but nettle could not inhibit collagen-induced aggregation. In contrast, nettle was the most potent inhibitor (66%) of whole blood aggregation induced by collagen, followed by alfalfa (52%), and camomile (30%) compared with control (P < 0.05). None of these three herbs however could inhibit arachidonic acid or thrombin induced platelet aggregation. Camomile and alfalfa strongly inhibited thromboxane B2 synthesis induced by ADP or collagen, but nettle had no effect. Alfalfa and nettle increased cGMP levels in platelets by 50 and 35%, respectively, compared with the control (1.85 +/- 0.23 nM) (P < 0.005). All these data indicate that camomile, nettle and alfalfa have potent anti-platelet properties, and their inhibitory actions are mediated via different mechanisms.
机译：研究了几种草药的水提取物在体外对人血小板聚集的影响。在研究的28种草药/营养食品中，甘菊，荨麻苜蓿，大蒜和洋葱表现出最显着的抗血小板活性（抑制作用≥45％）。与对照相比，苜蓿，新鲜荨麻和甘菊的水提取物分别抑制ADP诱导的血小板凝集73％，6​​5％和60％（P <0.05）。甘菊和苜蓿分别抑制胶原蛋白诱导的血小板凝集84％和65％，但是荨麻不能抑制胶原蛋白诱导的血小板凝集。相比之下，与对照相比，荨麻是胶原蛋白诱导的全血凝集的最有效抑制剂（66％），其次是苜蓿（52％）和甘菊（30％）（P <0.05）。然而，这三种草药均不能抑制花生四烯酸或凝血酶诱导的血小板凝集。甘菊和苜蓿强烈抑制ADP或胶原蛋白诱导的血栓烷B2合成，但荨麻没有作用。与对照相比（1.85 +/- 0.23 nM），苜蓿和荨麻分别使血小板中的cGMP水平增加了50％和35％（P <0.005）。所有这些数据表明甘菊，荨麻和苜蓿具有强大的抗血小板特性，它们的抑制作用是通过不同的机制介导的。

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