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The effect of aspirin on mean platelet volume in patients with paroxysmal atrial fibrillation

机译：阿司匹林对阵发性心房颤动患者平均血小板容量的影响

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Aspirin is one of the preferred therapies in the primary prevention of ischemic stroke in paroxysmal atrial fibrillation (PAF). Mean platelet volume (MPV) is a marker of platelet size and activation. Increased MPV reflects active and large platelets. The present observational study was designed to investigate whether aspirin treatment does affect MPV levels in patients with PAF. The study included 101 patients who were detected to have PAF by 24-hour Holter monitoring and divided into two groups based on aspirin treatment [ASA (+) and ASA (-)]. MPV was measured. Patients with aortic and mitral stenosis, hyperthyroidism, hypothyroidism, malignancy, infection, and pregnancy were excluded from the study. Of the 101 patients, 50 had no antiplatelet therapy and 51 had daily aspirin (100 mg) intake. Mean age of the patients was 66 ± 10 years and 35 (68%) were male in ASA (+) group. There was no difference in median levels of MPV (9.9 vs. 10.2 fl, respectively; p = 0.9) between groups. Both uni- and multivariate logistic regression analyses did not show an association between MPV and ASA use. Our results indicate that MPV as a predictive marker of platelet size and activity is not affected by aspirin use in patients with PAF.
机译：阿司匹林是阵发性房颤（PAF）一级预防缺血性卒中的首选疗法之一。血小板平均体积（MPV）是血小板大小和活化的标志。 MPV增加反映了活跃的血小板和大的血小板。本观察性研究旨在调查阿司匹林治疗是否确实会影响PAF患者的MPV水平。该研究包括101名通过24小时动态心电图监测检测出患有PAF的患者，并根据阿司匹林治疗分为两组[ASA（+）和ASA（-）]。测定MPV。该研究排除了主动脉和二尖瓣狭窄，甲状腺功能亢进，甲状腺功能低下，恶性肿瘤，感染和怀孕的患者。在101例患者中，有50例未接受抗血小板治疗，而51例每天摄入阿司匹林（100毫克）。 ASA（+）组的患者平均年龄为66±10岁，男性为35（68％）。两组之间的MPV中位数水平无分别（分别为9.9和10.2 fl; p = 0.9）。单变量和多变量逻辑回归分析均未显示MPV与ASA使用之间的关联。我们的结果表明，MPV作为血小板大小和活性的预测指标不受阿司匹林在PAF患者中的使用的影响。

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