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Paraneoplastic thrombocytosis in gastrointestinal cancer

机译：胃肠癌的副肿瘤性血小板增多症

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It has been demonstrated recently in several solid tumors that thrombocytosis at diagnosis may correlate with tumor invasion, metastatic progression and worse outcome. Several details of the pathomechanism of the relationship of thrombocytosis and cancer have been elucidated; however, the complete process is not clearly understood. Several hypotheses have been proposed. Recently, it was suggested that in ovarian cancer elevated IL-6 production by the tumor may induce increased megakaryopoiesis via hepatic thrombopoietin production leading to thrombocytosis. The importance of the prognostic power of elevated platelet count is still debated in gastrointestinal cancer. The aims of this review were to evaluate the prognostic significance of thrombocytosis in gastrointestinal tumors, to see whether clinical practice confirmed the hypotheses and to reveal the causes of the inconsistent findings.
机译：最近在几种实体瘤中已证实，诊断时的血小板增多可能与肿瘤浸润，转移进展和较差的预后相关。阐明了血小板增多与癌症关系的致病机理的一些细节。但是，整个过程尚不清楚。已经提出了几种假设。最近，有人提出在卵巢癌中，由肿瘤产生的高水平的IL-6可能通过肝血小板生成素的产生而导致巨核细胞增多，从而导致血小板增多。在胃肠道癌症中，血小板计数升高对预后的重要性仍存在争议。这篇综述的目的是评估血小板增多症在胃肠道肿瘤中的预后意义，以观察临床实践是否证实了这一假设并揭示不一致发现的原因。

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