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首页> 外文期刊>Platelets >Increased platelet reactivity in unstable angina patients is not related to C-reactive protein levels.
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Increased platelet reactivity in unstable angina patients is not related to C-reactive protein levels.

机译：不稳定型心绞痛患者的血小板反应性增加与C反应蛋白水平无关。

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Platelets are a major component of thrombi, and coronary thrombosis plays a key role in the pathogenesis of unstable angina (UA). Whether platelet aggregability is increased in UA patients however, is not known. Furthermore, no study has investigated the relationship between platelet reactivity and inflammation in UA patients In this study, venous blood samples were collected at admission in coronary care unit in 37 patients with unstable angina (Braunwald class IIIB) and in 37 sex- and age-matched patients with chronic stable angina (CSA). Patients taking thienopyridine or anticoagulant drugs were excluded from the study, as also were excluded patients with a history of acute myocardial infarction in the previous 12 months. Platelet aggregability was measured on flowing blood as time to occlude a ring coated with collagen-adenosine diphosphate (ADP), using the platelet function analyzer (PFA-100) system. By this method, the time to occlusion (closure time) is taken as a measure of platelet adhesion/aggregability, with shorter times indicating greater platelet reactivity.There were 23 men and 14 women in both groups, and age was 67.7 +/- 8 and 67.5 +/- 8 years in UA and SA, respectively (P = 0.93). Closure time was significantly reduced in UA patients (78.8 +/- 14 s), compared to SA patients (93.3 +/- 19 s, P < 0.001). Among UA patients, serum C-reactive protein (CRP) levels had a median value of 5.1 mg/l (bottom and top quartile levels, 1.50-7.95). There was no significant correlation between closure time and CRP levels (r = 0.22, P = 0.29). Our data show that, in patients with unstable angina there is an increase of platelet reactivity in response to ADP/collagen stimulation, which is not related to inflammation.
机译：血小板是血栓的主要成分，冠状动脉血栓形成在不稳定型心绞痛（UA）的发病机理中起关键作用。但是，UA患者的血小板凝集能力是否增加尚不清楚。此外，还没有研究调查UA患者血小板反应性与炎症之间的关系。在这项研究中，入院时在37例不稳定型心绞痛（Braunwald IIIB级）和37例性别和年龄的冠心病监护病房中收集了静脉血样本。与患有慢性稳定型心绞痛（CSA）的患者匹配。该研究排除了服用噻吩并吡啶或抗凝药的患者，也排除了在过去12个月中有急性心肌梗塞病史的患者。使用血小板功能分析仪（PFA-100），在流动的血液上测量血小板的凝集性，以观察其是否封闭了涂有二磷酸胶原-腺苷（ADP）的环。通过这种方法，将闭塞时间（闭合时间）作为血小板粘附/聚集性的量度，时间越短表明血小板的反应性越好。两组分别为23名男性和14名女性，年龄为67.7 +/- 8 UA和SA分别为67.5 +/- 8岁（P = 0.93）。与SA患者（93.3 +/- 19 s，P <0.001）相比，UA患者的闭合时间显着减少（78.8 +/- 14 s）。在UA患者中，血清C反应蛋白（CRP）水平的中值为5.1 mg / l（最低和最高四分位数水平为1.50-7.95）。关闭时间与CRP水平之间无显着相关性（r = 0.22，P = 0.29）。我们的数据表明，患有不稳定型心绞痛的患者响应ADP /胶原蛋白刺激而血小板反应性增加，这与炎症无关。

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