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首页> 外文期刊>Platelets >Platelet function in cutaneous diseases.
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Platelet function in cutaneous diseases.

机译：皮肤疾病中的血小板功能。

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Blood platelets participate actively in immune-inflammatory processes. Responding to the variety of stimuli such as cell activation leads to the release of several mediators, including RANTES, platelet factor 4, beta-thromboglobulin, thymus and activation-regulated chemokine (TARC/CCL17), serotonin and arachidonic acid metabolites. It also affects the expression of immunomodulatory and adhesive molecules, including CD154 and P-selectin. Immune-inflammatory processes associated with skin diseases could induce platelet activation, which, in turn, would contribute to acceleration and modulation of these processes. Activated platelets are capable of facilitating leukocyte rolling in the skin and the release of skin inflammation mediators. Changes in platelet function and behaviour may occur in certain types of skin inflammatory conditions and platelets might then be an important effector cell of the skin immune system, contributing to the pathogenesis of some skin inflammatory disorders. The changes in platelet activity and reactivity have been demonstrated to show distinctly different pathogenic mechanisms in cutaneous diseases, such as urticaria, atopic eczema/dermatitis syndrome and psoriasis. Considering the risk of cardiovascular events, some of them seem to be of clinical significance. This contribution is a brief outline of the present knowledge of the platelet function in dermal disorders.
机译：血小板积极参与免疫炎症过程。对各种刺激（例如细胞激活）做出反应会导致释放多种介质，包括RANTES，血小板因子4，β-血球蛋白，胸腺和激活调节趋化因子（TARC / CCL17），5-羟色胺和花生四烯酸代谢产物。它还会影响免疫调节分子和粘附分子（包括CD154和P-选择蛋白）的表达。与皮肤疾病相关的免疫炎症过程可能会诱导血小板活化，进而促进这些过程的加速和调节。活化的血小板能够促进白细胞在皮肤中滚动和释放皮肤炎症介质。在某些类型的皮肤炎性疾病中，血小板功能和行为的改变可能发生，然后血小板可能是皮肤免疫系统的重要效应细胞，导致某些皮肤炎性疾病的发病机理。已经证明血小板活性和反应性的变化显示出在皮肤疾病如荨麻疹，特应性湿疹/皮炎综合征和牛皮癣中明显不同的致病机理。考虑到心血管事件的风险，其中一些似乎具有临床意义。该贡献是对皮肤疾病中血小板功能的当前知识的简要概述。

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