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Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation

机译:短的线性图案:遍在和功能多样的蛋白质相互作用模块指导细胞调节。

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摘要

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to mediate the functions required for cell viability. Specific, context-dependent and tightly controlled physical interactions between these cellular components govern the necessary physiological processes, from cell division to cell death. The specificity, conditionality, and regulation of these binding events depend on communication between the interacting molecules and their surroundings. For proteins, most of this communication is mediated by a variety of modules that are embedded within the protein sequence, can bind a wide array of ligands, and have catalytic, regulatory, or scaffolding activity. These functional units enable proteins to sense, integrate, and transmit environmental and cell state indicators and concomitantly instigate cellular decisions based on the information available to the system.
机译:真核细胞是一个繁华的大分子集合,它们协同作用以介导细胞活力所需的功能。这些细胞成分之间的特定,依赖于上下文且受到严格控制的物理相互作用控制着必要的生理过程,从细胞分裂到细胞死亡。这些结合事件的特异性,条件和调节取决于相互作用的分子与其周围环境之间的交流。对于蛋白质,大多数这种交流是由嵌入蛋白质序列中的各种模块介导的,它们可以结合多种配体,并具有催化,调节或支架活性。这些功能单元使蛋白质能够感应,整合和传输环境和细胞状态指示剂,并根据系统可用的信息来激发细胞的决定。

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