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Special issue focused on the International Symposium on Biology and Translational Aspects of Neurodegeneration at Venice, Italy, March 2012

机译：特刊以2012年3月在意大利威尼斯举行的关于神经变性的生物学和转化方面的国际研讨会为重点

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This Special Issue of Priori may seem unusual, as prions are but one of the topics of much discussion; the focus is much wider, and covers the entire spectrum of neurodegenerative diseases. This issue collects some of the papers presented at the International Symposium on Biology and Translational Aspects of Neurodegeneration in March 2012. Once again, the Symposium was held in the beautiful venue of Palazzo Cavalli-Franchetti, which is the seat of the Venetian Institute of Sciences, Letters and Arts on the Grand Canal of Venice. Even if not directly on the forefront of the Symposium, prions were frequently in the background, as the concept of the prion-like behavior of some neurodegeneration-related proteins was extensively discussed. In addition, the idea that the prion protein could mediate the toxic effects of misfolded proteins in pathologies like Alzheimer disease also received considerable attention. The presentations focused on molecular mechanisms, but related topics were also considered, e.g., the clinical implications of the basic science findings made. The scientific content of the presentations was very high and generated intense and fruitful discussions.
机译：这本《先验》特刊可能看起来不寻常，因为病毒只是众多讨论的主题之一;重点更加广泛，涵盖了神经退行性疾病的整个领域。本期收集了在2012年3月国际生物学和神经变性的转化方面国际研讨会上发表的一些论文。该研讨会再次在美丽的威尼斯科学研究院所在地卡瓦利-弗朗切蒂宫举行。 ，威尼斯大运河上的信件和艺术。即使不是直接在研讨会的最前沿，病毒也经常出现在背景中，因为一些神经变性相关蛋白的proteins病毒行为的概念已被广泛讨论。此外，that病毒蛋白可以介导错误折叠的蛋白在诸如阿尔茨海默氏病等病理中的毒性作用的观点也受到了相当大的关注。报告着重于分子机制，但也考虑了相关主题，例如，基础科学发现的临床意义。演讲的科学性很高，引起了激烈而富有成果的讨论。

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