Atazanavir: new indication. First-line treatment: fewer gastrointestinal disorders but more cases of jaundice and a risk of torsades de pointes.

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Atazanavir: new indication. First-line treatment: fewer gastrointestinal disorders but more cases of jaundice and a risk of torsades de pointes.

机译：阿扎那韦：新的适应症。一线治疗：胃肠道疾病较少，但黄疸病例较多，有发生尖端扭转性脉搏的风险。

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On the basis of a single clinical trial in first-line treatment, the atazanavir and ritonavir combination appears to be no more effective than the fixed-dose combination of lopinavir and ritonavir. The adverse effect profiles were slightly different, but atazanavir carries a troubling risk of torsades de pointes.

机译：根据一线治疗的一项临床试验，阿扎那韦和利托那韦的组合似乎没有比洛匹那韦和利托那韦的固定剂量组合更有效。不良反应情况略有不同，但是阿扎那韦具有尖锐的扭转性交感的危险。

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《Prescrire international》 |2009年第101期|共1页
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正文语种 eng
中图分类药学;
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1. Atazanavir: new indication. First-line treatment: fewer gastrointestinal disorders but more cases of jaundice and a risk of torsades de pointes. [J] . Prescrire international . 2009,第101期

机译：阿扎那韦：新的适应症。一线治疗：胃肠道疾病较少，但黄疸病例较多，有发生尖端扭转性脉搏的风险。
2. Predicting the degree of drug-induced QT prolongation and the risk for torsades de pointes. [J] . Ding C Heart rhythm: the official journal of the Heart Rhythm Society . 2011,第10期

机译：预测药物诱导的QT延长的程度和尖端扭转型室速的风险。
3. Magnitude of QT prolongation associated with a higher risk of Torsades de Pointes. [J] . Lin YL, Kung MF Pharmacoepidemiology and drug safety . 2009,第3期

机译：QT延长的幅度与较高的Torsades de Pointes风险相关。
4. Drug-Induced Torsade de Pointes. Role of Genetic Factors [C] . N. EL SHERIF, G. TURITTO International Workshop on Cardiac Arrhythmias . 2004

机译：药物引起的扭转de指向。遗传因素的作用
5. Managing bipolar disorder in pregnancy: Risks, benefits of pharmacologic and alternative treatments. [D] . Alt, Donna J. 2010

机译：在妊娠中治疗双相情感障碍：药物治疗和替代治疗的风险，收益。
6. Primary hyperparathyroidism presenting as torsades de pointes. [O] . P Kearney, M Reardon, J OHare 1993

机译：原发性甲状旁腺功能亢进表现为尖端扭转型。
7. The relationship between early afterdepolarization and the occurrence of torsades de pointes. An in vivo canine model study. [O] . TADASHI SATO, KENZO HIRAO, KAZUMASA HIEJIMA 1993

机译：早期后偏极化与扭曲的发生之间的关系。一个在体内犬模型研究。
8. Incidence and Gastrointestinal Infectious Risk of Functional Gastrointestinal Disorders in a Healthy US Adult Population [R] . Porter, C. K., Gormley, R., Tribble, D. R., 2011

机译：美国健康成年人群中功能性胃肠道疾病的发病率和胃肠传染风险

Atazanavir: new indication. First-line treatment: fewer gastrointestinal disorders but more cases of jaundice and a risk of torsades de pointes.

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