Poorly effective in those who need it most

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Poorly effective in those who need it most

机译：对最需要的人效果不佳

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The results of a clinical trial suggest that zoster vaccination (Zostavax0, Sanofi Pasteur MSD) of 1000 healthy persons aged 60 years or over prevents approximately one case of postherpetic neuralgia each year over the next 3 years. Vaccination is less effective in persons over 70 years of age.The results of another clinical trial suggest that vaccination of 1000 healthy persons aged 50 to 59 years prevents about 5 cases of herpes zoster over the following year. The impact on the frequency of postherpetic neuralgia is not known.The vaccine might not be protective in persons who subsequently become immunocompromised.

机译：临床试验结果表明，在接下来的3年中，每年有1000名60岁或60岁以上的健康人进行带状疱疹疫苗接种（Zostavax0，Sanofi Pasteur MSD）可以预防每年约1例带状疱疹后神经痛。接种疫苗对70岁以上的人效果较差。另一项临床试验的结果表明，对1000名年龄在50至59岁的健康人进行疫苗接种可在第二年预防5例带状疱疹。目前尚不知道其对疱疹后神经痛发生频率的影响，该疫苗可能对后来免疫功能低下的人没有保护作用。

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《Prescrire international》 |2012年第133期|共1页
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Poorly effective in those who need it most

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