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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Trends in plasma cholesterol levels in the atherosclerosis risk in communities (ARIC) study.
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Trends in plasma cholesterol levels in the atherosclerosis risk in communities (ARIC) study.

机译：社区中动脉粥样硬化风险中血浆胆固醇水平的趋势（ARIC）研究。

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BACKGROUND: Data from the Atherosclerosis Risk in Communities (ARIC) cohort study were examined both cross-sectionally and intraindividually to confirm recent findings from population-based studies showing a decline in total cholesterol (TC) levels in the United States. METHODS: For the cross-sectional analysis, mean plasma TC levels from 15,792 participants aged 45-64 at baseline visit, and who were selected randomly from four U.S. communities, were examined for each year covered by the first cohort visit (1987, 1988, and 1989). Ninety-three percent of the cohort participants returned for the follow-up visit (1990, 1991, and 1992), and were included in the assessment of intraindividual TC trends. RESULTS: Both mean TC and prevalence of hypercholesterolemia (defined as plasma cholesterol concentration >/=240 mg/dl) consistently declined over the 3 years covered by visit 1 for all age-gender-race groups. For 1987, 1988, and 1989, mean TC values (mg/dl) were, respectively, 220.3, 216.7, and 214.1 (annual average change, -1.4%, P < 0.001). For these same years, hypercholesterolemia prevalence rates were 30. 0, 27.8, and 25.3% (annual average change, -7.8%, P < 0.001). The mean plasma TC also decreased within individuals between the two visits across race, gender, and age decade categories. With the exception of black men, this decline was more marked for older than younger subjects, but no consistent differences were seen between the racial groups. However, in whites, decreases were greater for men than for women. Expected results were seen when these changes were correlated with changes in cardiovascular risk factors between the two visits. CONCLUSION: The current study results are consistent with those of previous studies, and confirm the notion that preventive programs appear to be effective in reducing mean population TC levels.
机译：背景：对社区的动脉粥样硬化风险（ARIC）队列研究的数据进行了横断面和病历分析，以确认基于人群的研究的最新发现，这些研究表明美国总胆固醇（TC）水平下降。方法：为进行横断面分析，在首次队列访问（1987年，1988年，和1989年）。队列参与者中有93％返回了随访（1990年，1991年和1992年），并且被纳入了个体间TC趋势的评估中。结果：所有年龄性别组的随访1所涵盖的3年中，平均TC和高胆固醇血症患病率（定义为血浆胆固醇浓度> / = 240 mg / dl）均持续下降。 1987年，1988年和1989年的平均TC值（mg / dl）分别为220.3、216.7和214.1（年平均变化，-1.4％，P <0.001）。在这些年中，高胆固醇血症的患病率分别为30. 0、27.8和25.3％（年平均变化，-7.8％，P <0.001）。两次访视之间，种族，性别和年龄十年类别的平均血浆TC也降低。除黑人外，年龄下降的趋势明显比年轻的受试者明显，但种族群体之间没有一致的差异。但是，在白人中，男性的下降幅度大于女性。当这些变化与两次就诊之间的心血管危险因素的变化相关时，可以看到预期的结果。结论：目前的研究结果与以前的研究结果一致，并证实了预防方案似乎在降低平均人群TC水平方面有效的观点。

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