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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Reduction of plasma catecholamines in humans during clinically controlled severe underfeeding.
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Reduction of plasma catecholamines in humans during clinically controlled severe underfeeding.

机译：在临床控制的严重食物不足期间减少人血浆儿茶酚胺。

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BACKGROUND: Sympathetic hyperactivity is one factor for alterations encountered in the plurimetabolic syndrome, a cluster of metabolic abnormalities including obesity, hyperlipidemia, sometimes hyperglycaemia, and hypertonia. It was interesting to know if prolonged severe underfeeding (230 kcal/day) leads to decreases in catecholamines in those patients. METHODS: The plasma concentrations of catecholamines in patients (n = 16) suffering from plurimetabolic syndrome were studied before and during a 16-day period of medically controlled severe underfeeding (230 kcal/day) at rest and in response to exercise. RESULTS: During the period of underfeeding, mean norepinephrine concentrations decreased at rest from 1.45 to 0. 96 nmol/liter, and in response to exercise, from 6.1 to 3.2 nmol/liter. Epinephrine concentrations decreased from 0.15 to 0.1 nmol/liter and from 0.26 to 0.17 nmol/liter, respectively. A significant decrease in catecholamine concentrations was observed only after 16 days of underfeeding. CONCLUSIONS: Clinically controlled underfeeding of patients with plurimetabolic syndrome may result in beneficial clinical and biochemical effects. The findings indicate that relatively long periods of underfeeding induce decreases in plasma catecholamine concentrations. Nevertheless, most of the fall in mean values in norepinephrine and also of the fall in blood pressure values occurred by Day 2. From those tendencies and from the significant changes in both parameters at Day 16 of severe underfeeding one could conclude that altered sympathetic nervous system activity could contribute to the fall in blood pressure. Copyright 2000 American Health Foundation and Academic Press.
机译：背景：交感神经亢进是导致多代谢综合征（包括肥胖症，高脂血症，有时高血糖症和高渗症）的代谢异常的一个因素。有趣的是，长时间的严重喂养不足（230 kcal /天）是否会导致这些患者的儿茶酚胺减少。方法：研究了在静息和运动对药物控制的严重不足食物（230 kcal /天）的16天之前和之中，患有多代谢综合征的患者（n = 16）血浆儿茶酚胺的浓度。结果：在进食不足期间，去甲肾上腺素的平均浓度从休息时的1.45降至0. 96 nmol /升，而在运动时则从6.1降至3.2 nmol /升。肾上腺素浓度分别从0.15降至0.1 nmol /升和从0.26降至0.17 nmol /升。仅在喂食不足16天后，儿茶酚胺浓度才显着下降。结论：多代谢综合征患者的临床控制喂养不足可能导致有益的临床和生化作用。这些发现表明，相对长期的食物不足会导致血浆儿茶酚胺浓度降低。然而，去甲肾上腺素平均值的大多数下降以及血压值的下降大多发生在第2天。从这些趋势和严重不足食物的第16天两个参数的显着变化中，可以得出结论，交感神经系统发生了变化活动可能会导致血压下降。版权所有2000美国健康基金会和学术出版社。

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