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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >omega-3 polyunsaturated fatty acids and depression: A review of the evidence and a methodological critique.
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omega-3 polyunsaturated fatty acids and depression: A review of the evidence and a methodological critique.

机译：ω-3多不饱和脂肪酸与抑郁症：证据综述和方法学评论。

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摘要

Several lines of evidence indicate an association between omega-3 polyunsaturated fatty acids (PUFAs) and depression. The purpose of this review was to evaluate the evidence to date within the context of the study design and methodology used. In case-control and cohort studies, concentrations of omega-3 PUFAs were lower in participants with unipolar and postpartum depression. Fish are the major dietary source of omega-3 PUFAs, and infrequent fish consumption is associated with depression in epidemiological studies. While these findings do not appear to be the result of confounding, in some studies failure to detect confounding may be due to a lack of power or incomplete control. In four of seven double-blind randomized controlled trials, depression was significantly improved upon treatment with at least 1 g/day of eicosapentaenoic acid, an omega-3 PUFA. While clinical significance was demonstrated, preservation of blinding may be a limitation in this area of research. It remains unclear whether omega-3supplementation is effective independently of antidepressant treatment, for depressed patients in general or only those with abnormally low concentrations of these PUFAs. The relationship between omega-3 PUFAs and depression is biologically plausible and is consistent across study designs, study groups, and diverse populations, which increases the likelihood of a causal relationship.
机译：几条证据表明，omega-3多不饱和脂肪酸（PUFA）与抑郁症之间存在关联。审查的目的是在研究设计和所用方法的背景下评估迄今为止的证据。在病例对照研究和队列研究中，患有单相和产后抑郁症的参与者的omega-3 PUFA浓度较低。鱼是omega-3 PUFA的主要饮食来源，在流行病学研究中，不经常食用鱼与抑郁症有关。尽管这些发现似乎不是混杂的结果，但在某些研究中，未能检测到混杂的原因可能是由于能力不足或控制不力所致。在七项双盲随机对照试验中的四项中，每天至少使用1 g二十碳五烯酸（一种omega-3 PUFA）治疗后，抑郁症得到了明显改善。尽管已证明了临床意义，但保持盲法可能是该研究领域的局限性。尚不清楚omega-3补充剂对一般的抑郁症患者或仅这些PUFA浓度异常低的患者是否独立于抗抑郁药治疗有效。 omega-3 PUFA与抑郁之间的关系在生物学上是合理的，并且在研究设计，研究组和不同人群之间是一致的，这增加了因果关系的可能性。

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