Omalizumab 75 mg. Whatever the dosage, the drug should be avoided in severe persistent asthma.

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Omalizumab 75 mg. Whatever the dosage, the drug should be avoided in severe persistent asthma.

机译：奥马珠单抗75毫克。无论剂量如何，在严重的持续性哮喘中均应避免使用该药物。

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Omalizumab (Xolairdeg, Novartis) is an anti-IgE monoclonal antibody authorised for the treatment of selected adults and children 6 years of age and older with severe persistent allergic asthma associated with high blood IgE levels, who are inadequately relieved by inhaled corticosteroids and long-acting inhaled beta-2 agonists (1, 2,3). Efficacy of omalizumab in these patients is uncertain but adverse effects are frequent, including hypersensitivity reactions (anaphylactic shock, angioede-ma, skin rash), thrombocytopenia, ischaemic heart disease, cerebrovas-cular disorders, and injection site reactions. Concerns have been raised about a possible risk of cancer and infections (2,3).

机译：Omalizumab（Xolairdeg，Novartis）是一种抗IgE单克隆抗体，已授权用于治疗部分选定的成人和6岁及以上的儿童，患有严重的持续性过敏性哮喘，并伴有高血IgE水平，这些患者因吸入糖皮质激素和长期使用吸入β-2激动剂（1、2、3）。奥马珠单抗在这些患者中的疗效尚不确定，但不良反应频繁，包括过敏反应（过敏性休克，血管性血管瘤，皮疹），血小板减少症，缺血性心脏病，脑血管疾病和注射部位反应。人们对癌症和感染的可能风险提出了担忧（2,3）。

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《Prescrire international》 |2011年第121期|共1页
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1. Omalizumab 75 mg. Whatever the dosage, the drug should be avoided in severe persistent asthma. [J] . Anonymous Prescrire international . 2011,第121期

机译：奥马珠单抗75毫克。无论剂量如何，在严重的持续性哮喘中均应避免使用该药物。
2. Effectiveness of omalizumab in reducing corticosteroid burden in patients with moderate to severe persistent allergic asthma. [J] . Karpel J, Massanari M, Geba GP, Annals of allergy, asthma, and immunology . 2010,第6期

机译：omalizumab减轻中度至重度持续性过敏性哮喘患者皮质类固醇激素负担的有效性。
3. Effectiveness of omalizumab in patients 50 years and older with severe persistent allergic asthma. [J] . Korn S, Schumann C, Kropf C, Annals of allergy, asthma, and immunology . 2010,第4期

机译：omalizumab在50岁及以上的严重持续性过敏性哮喘患者中的疗效。
4. TACHISTOSCOPIC STUDY ON THE IMPACT OF NET QUANTITY AND DOSAGE STRENGTH PROXIMITY ON DOSAGE STRENGTH RECOGNITION IN PRESCRIPTION DRUG LABELS [C] . Kevin Buffardi, Agnieszka Bojko, Edmond Israelski Annual Meeting of the Human Factors and Ergonomics Society(HFES 2007); 20071001-05; Baltimore,MA(US) . 2007

机译：处方药标签中净量和剂量强度接近度对剂量强度识别的影响的梯形研究
5. Part I. Rapid analysis of pharmaceutical compounds using high-speed HPLC columns. Part II. Simulataneous determination of drugs in tablet dosage forms using packed column supercritical fluid chromatography. Part III. Pharmaceutical analysis of selected drugs using capillary electrophoresis. [D] . Zhou, Meng. 2001

机译：第一部分：使用高速HPLC色谱柱对药物化合物进行快速分析。第二部分使用填充柱超临界流体色谱法同时测定片剂剂型中的药物。第三部分使用毛细管电泳对选定药物进行药物分析。
6. Effect of omalizumab as add-on therapy to Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) in Korean patients with severe persistent allergic asthma [O] . Jae-Woo Jung, Hae-Sim Park, Choon-Sik Park, 2021

机译：omalizumab作为韩国哮喘（KAQLQ）对韩国哮喘患者严重持续过敏哮喘的韩国哮喘（KAQLQ）的疗效问卷的影响
7. Cost-Effectiveness of Bronchial Thermoplasty, Omalizumab, and Standard Therapy for Moderate-to-Severe Allergic Asthma. [O] . Zafar Zafari, Mohsen Sadatsafavi, Carlo A Marra, 2016

机译：支气管热成形术，奥马珠单抗和中度至重度过敏性哮喘的标准疗法的成本效益。

Omalizumab 75 mg. Whatever the dosage, the drug should be avoided in severe persistent asthma.

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