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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Primordial prevention of cardiovascular disease through applied genetics.
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Primordial prevention of cardiovascular disease through applied genetics.

机译：通过应用遗传学来预防心血管疾病。

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摘要

Primordial prevention might be considered prevention of the development of disease at its earliest stages or early intervention on risk factors to eliminate increased risk in the first place. In this review we consider how knowledge of genetic causes of early cardiovascular disease can lead to directed screening and better treatment of high risk individuals. While gene therapy would be the most "primordial" approach to prevention of some diseases such as familial hypercholesterolemia, its practical application remains on the horizon. Nevertheless, there is much we can do now to prevent early deaths in genetically high risk patients. Here we consider epidemiology as the parent discipline for applied genetics and as integral to primordial prevention. With new knowledge of special susceptibility and new understanding of the interaction of genetics and exposures, prevention of individual high-risk in the first place is realizable. We summarize here the known and candidate genes influencing atherosclerosis, hypertension, and thrombosis; their diagnosis; and some useful preventive approaches. MEDPED, an international scheme for detection of risk in medical pedigrees, is described, along with the cost and social implications of its application as a preventive strategy.
机译：最初的预防可以被认为是在疾病的早期阶段预防疾病的发展，或者可以从一开始就对危险因素进行早期干预以消除增加的危险。在这篇综述中，我们考虑了早期心血管疾病遗传原因的知识如何导致定向筛查和对高风险个体的更好治疗。尽管基因疗法将是预防某些疾病（如家族性高胆固醇血症）的最“原始”方法，但其实际应用仍在眼前。尽管如此，我们现在有很多工作可以预防遗传高危患者的早期死亡。在这里，我们认为流行病学是应用遗传学的父学科，也是原始预防的组成部分。有了对特殊药敏性的新知识以及对遗传学和暴露之间相互作用的新理解，首先就可以实现个人高风险的预防。我们在这里总结了影响动脉粥样硬化，高血压和血栓形成的已知基因和候选基因。他们的诊断;以及一些有用的预防方法。介绍了MEDPED，这是一种用于检测医学谱系中的风险的国际计划，并介绍了其作为预防策略的成本和社会影响。

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