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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >The effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysis.
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The effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysis.

机译：戒烟对血脂和脂蛋白谱的影响：一项荟萃分析。

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BACKGROUND: Cross-sectional studies revealed that cigarette smokers have lower high-density lipoprotein cholesterol (HDL-C) levels and higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) than nonsmokers. But prospective studies on the effects of cigarette smoking cessation on lipid profile have yielded inconclusive results. METHODS: Relevant English articles were retrieved by keyword searches of MEDLINE (1966-October 2000), Cochrane Library (2000, Issue 2), and cited references. Twenty-seven studies met the following inclusion criteria: (1) prospective cohort study including clinical trials, (2) measuring smoking status and lipid profile of HDL-C, TC, LDL-C, and TG, (3) reporting the changes of lipid concentrations in abstinent smokers, and (4) not using adjuvant antihyperlipidemic drugs. RESULTS: Overall Q statistics for net change of HDL-C, TC, LDL-C, and TG showed heterogeneity. Using a random-effects model, HDL-C level increased significantly[0.100 (CI 0.074 to 0.127) mmol/L] after smoking cessation. However, levels of TC [+0.003 (CI -0.042 to 0.048)], LDL-C [-0.064 (CI -0.149 to 0.021)], and TG [+0.028 (CI -0.014 to 0.071)] did not change significantly after smoking cessation. CONCLUSIONS: Cigarette smoking cessation increases serum levels of HDL-C but not of TC, LDL-C, and TG.
机译：背景：横断面研究显示，吸烟者的高密度脂蛋白胆固醇（HDL-C）水平较低，总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C）和甘油三酸酯（TG）含量较高不吸烟者。但是关于戒烟对血脂状况影响的前瞻性研究未得出结论。方法：通过MEDLINE（1966年-2000年10月），Cochrane图书馆（2000年，第2期）的关键词搜索来检索相关的英语文章，并引用参考文献。二十七项研究符合以下纳入标准：（1）包括临床试验在内的前瞻性队列研究;（2）测量HDL-C，TC，LDL-C和TG的吸烟状况和脂质状况;（3）报告戒烟者的血脂浓度;以及（4）不使用辅助降血脂药。结果：HDL-C，TC，LDL-C和TG净变化的总体Q统计显示异质性。使用随机效应模型，戒烟后，HDL-C水平显着升高[0.100（CI 0.074至0.127）mmol / L]。但是，TC [+0.003（CI -0.042至0.048）]，LDL-C [-0.064（CI -0.149至0.021）]和TG [+0.028（CI -0.014至0.071）]的水平在之后没有明显变化。戒烟。结论：戒烟增加了HDL-C的血清水平，但没有增加TC，LDL-C和TG的血清水平。

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