Growth hormone: brain haemorrhage

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Growth hormone: brain haemorrhage

机译：生长激素：脑出血

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Somatropin, a growth hormone analogue, carries a long-term risk of cancer and diabetes, although these adverse effects have not been accurately quantified (1).A long-term French epidemiological study included 10 000 young adults who had received somatropin during childhood for growth retardation between 1985 and 1996 (1,2). When the mortality rate among these patients was analysed in 2010, it was found to be higher than normal, mainly due to stroke and bone tumours. Additional data about haemor-rhagic stroke were published in 2014.

机译：生长激素类似物生长激素（Somatropin）具有长期患癌症和糖尿病的风险，尽管尚未准确量化这些不良反应（1）。法国的一项长期流行病学研究包括1万名在儿童期接受过生长激素的年轻人1985年至1996年之间的增长迟缓（1,2）。在2010年对这些患者的死亡率进行分析时，发现该死亡率高于正常水平，主要是由于中风和骨肿瘤。 2014年发布了有关流血性多发性中风的其他数据。

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《Prescrire international》 |2015年第159期|共1页
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1. Growth hormone: brain haemorrhage [J] . Prescrire international . 2015,第159期

机译：生长激素：脑出血
2. Antagonists of growth hormone-releasing hormone cross the blood-brain barrier: A potential applicability to treatment of brain tumors [J] . Jaeger LB, Banks WA, Varga JL, Proceedings of the National Academy of Sciences of the United States of America . 2005,第35期

机译：生长激素释放激素的拮抗剂穿越血脑屏障：治疗脑肿瘤的潜在适用性
3. Occurrence of Cranial Neoplasms in Pediatric Patients with Noonan Syndrome Receiving Growth Hormone: Is Screening with Brain MRI prior to Initiation of Growth Hormone Indicated? [J] . Krishna Kanthi Bangalore, Pagan Pedro, Escobar Oscar, Hormone research in p?diatrics . 2017,第6期

机译：Noonan综合征接受生长激素的儿科患者颅内肿瘤发生：在发育生长激素之前用脑MRI筛选出来的？
4. Diabetes aggravates heat stress-induced blood-brain barrier breakdown, reduction in cerebral blood flow, edema formation, and brain pathology Possible neuroprotection with growth hormone [C] . Dafin F Muresanu, Aruna Sharma, Hari Shanker Sharma International Conference on Neuroprotective Agents: Clinical and Experimental Aspects . 2010

机译：糖尿病加剧热应激诱导的血脑屏障分解，减少脑血流量，水肿形成和脑病理可能的生长激素的神经保护作用
5. Mouse growth hormone-releasing hormone: Gene structure and expression of distinct transcripts in brain and placenta [D] . Suhr, Steven Thomas 1992

机译：小鼠生长激素释放激素：脑和胎盘中不同转录本的基因结构和表达
6. Antagonists of growth hormone-releasing hormone cross the blood-brain barrier: A potential applicability to treatment of brain tumors [O] . Laura B. Jaeger, William A. Banks, Jozsef L. Varga, 2005

机译：生长激素释放激素的拮抗剂穿越血脑屏障：治疗脑肿瘤的潜在适用性
7. Mechanisms and effects of growth hormone deficiency (due to subarachnoid haemorrhage and traumatic brain injury) on quality of life and regional body composition, and the influence of hormone replacement. [O] . Gardner C 100

机译：生长激素缺乏（由于蛛网膜下腔出血和创伤性脑损伤）对生活质量和区域体成分以及激素替代的影响的机制和作用。

Growth hormone: brain haemorrhage

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