Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet. Better adherence than with separate dosing has not been demonstrated, while reduced efficacy is plausible.

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Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet. Better adherence than with separate dosing has not been demonstrated, while reduced efficacy is plausible.

机译：依非韦伦+恩曲他滨+替诺福韦：新组合。 HIV感染：不要仅仅为了少吃一粒药片就修改正在进行的疗法。尚没有比单独给药更好的依从性，而降低的疗效似乎是合理的。

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First-line antiretroviral treatment for HIV infection consists of triple drug therapy, chosen on the basis of established efficacy, known adverse effects, risk of interactions and convenience of treatment (1). One of the best-evaluated combinations is lamivudine plus zidovu-dlne, combined with protease inhibitors or efavirenz. Tenofovir disoproxll is an alternative to zldovudine, but it exposes patients to a risk of serious renal impair-merit, if the dose is not adjusted to renal function, as well as a risk of bone toxic-ity (1,2,3). Emtricitabine is very similar to lamivudine (2).

机译：针对HIV感染的一线抗逆转录病毒治疗包括三重药物治疗，应根据既定的疗效，已知的不良反应，相互作用的风险和治疗的便利性进行选择（1）。评估效果最好的组合之一是拉米夫定加齐多夫丁，与蛋白酶抑制剂或依非韦伦合用。替诺福韦酯替索罗非可以替代齐多夫定，但如果不根据肾功能调整剂量，则会使患者面临严重肾功能不全的风险以及骨毒性（1,2,3）。恩曲他滨与拉米夫定非常相似（2）。

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《Prescrire international》 |2009年第101期|共1页
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1. Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet. Better adherence than with separate dosing has not been demonstrated, while reduced efficacy is plausible. [J] . Prescrire international . 2009,第101期

机译：依非韦伦+恩曲他滨+替诺福韦：新组合。 HIV感染：不要仅仅为了少吃一粒药片就修改正在进行的疗法。尚没有比单独给药更好的依从性，而降低的疗效似乎是合理的。
2. Fixed-dose combination emtricitabine/tenofovir/efavirenz initiated during acute HIV infection; 96-week efficacy and durability [J] . Gay Cynthia L., Willis Sarah J., Cope Anna B., AIDS . 2016,第18期

机译：在急性HIV感染期间开始固定剂量联合恩曲他滨/替诺福韦/依法韦仑治疗; 96周的功效和耐用性
3. Elvitegravir/cobicistat/emtricitabine/tenofovir DF (Quad) has durable efficacy and differentiated safety compared to efavirenz/emtricitabine/tenofovir DF at week 96 in treatment‐na?ve HIV‐1‐infected patients [J] . A Zolopa, J Gallant, C Cohen, Journal of the International Aids Society . 2012,第2期

机译：与未治疗过HIV-1感染的患者相比，在第96周时，与依非韦伦/恩曲他滨/替诺福韦DF相比，Elvitegravir / cobicistat / emtricitabine / tenofovir DF（Quad）具有持久的疗效和差异化的安全性
4. PrEP Adherence to Tenofovir-Based Therapeutics Seems Efficacious in Reducing HIV Infection Dissemination: A Comparative Evaluation on the Therapeutic Potency of Tenofovir-Based PrEP & Dapivirine-Based Antiretroviral (ARV) Microbicide in HIV Prevention [D] . Paria, Ananya. 2019

机译：准备遵守基于Tenofovir的治疗方法似乎有效地减少HIV感染传播：对邻西罗韦的制备基础抗逆转录病毒（ARV）杀菌剂中幼虫预防杀菌剂的比较评价
5. Fixed dose combination emtricitabine/tenofovir/efavirenz initiated during Acute HIV Infection; 96-week efficacy and durability [O] . Cynthia L. GAY, Sarah J. WILLIS, Anna B. COPE, -1

机译：在急性HIV感染期间开始固定剂量联合恩曲他滨/替诺福韦/依法韦仑治疗； 96周功效和耐用性
6. Issues in resistance, adherence, and comparative efficacy of the single-tablet regimen combination of tenofovir, emtricitabine, and efavirenz in the management of HIV-1 infection [O] . Sharon Walmsley 2012

机译：替诺夫罗维尔，Emtricistabine和Efaviraenz在HIV-1感染管理中的单片方案组合的抵抗力，依从性和比较疗效的问题

Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet. Better adherence than with separate dosing has not been demonstrated, while reduced efficacy is plausible.

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