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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Alpha-tocopherol supplementation for men with existing coronary artery disease: A feasibility study.
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Alpha-tocopherol supplementation for men with existing coronary artery disease: A feasibility study.

机译：患有现有冠状动脉疾病的男性补充α-生育酚：一项可行性研究。

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BACKGROUND: Recent studies have suggested that alpha-tocopherol supplementation can help reduce the incidence of coronary disease. Our objectives were to determine the feasibility of providing alpha-tocopherol supplements to male veterans with existing coronary artery disease and determine its effects on alpha-tocopherol levels and the susceptibility of low-density lipoprotein (LDL) to oxidation. METHODS: Fifty-seven percent of 138 coronary disease patients were willing to participate in a placebo-controlled trial -25% were already taking antioxidants. Thirty-nine men were randomly assigned to either 400 mg/day of alpha-tocopherol (n = 27) or placebo (n = 12). alpha-Tocopherol levels and LDL oxidation (measured by formation of thiobarbituric acid-reactive substance) were measured at baseline and at 6 months. RESULTS: Thirty-three subjects (22 alpha-tocopherol, 11 placebo) completed the study; 3 subjects withdrew after suffering coronary disease events. Supplement compliance exceeded 90% and alpha-tocopherol was well tolerated. The alpha-tocopherol group had a significantly greater mean increase in lipid-adjusted alpha-tocopherol levels (73% vs. -4.6%, P < 0.0001), but oxidized LDL did not change significantly. CONCLUSIONS: A secondary prevention trial among veterans would be feasible because the rates of enrollment, completion, compliance, and clinical events were high. alpha-Tocopherol supplements did not decrease the susceptibility of LDL to oxidation, suggesting that higher dosages or longer duration of supplementation may be required for secondary prevention. Copyright 1999 American Health Foundation and Academic Press.
机译：背景：最近的研究表明，补充α-生育酚可以帮助减少冠心病的发病率。我们的目标是确定向患有冠状动脉疾病的男性退伍军人提供α-生育酚补充剂的可行性，并确定其对α-生育酚水平的影响以及低密度脂蛋白（LDL）对氧化的敏感性。方法：138名冠心病患者中有57％愿意参加安慰剂对照试验，而-25％的患者已经服用了抗氧化剂。 39名男性被随机分配至400毫克/天的α-生育酚（n = 27）或安慰剂（n = 12）。在基线和6个月时测量α-生育酚水平和LDL氧化（通过形成硫代巴比妥酸反应性物质来测量）。结果：33位受试者（22位α-生育酚，11位安慰剂）完成了研究; 3名受试者在患有冠心病事件后退出。补充剂的依从性超过90％，α-生育酚的耐受性良好。 α-生育酚组的脂质调整后的α-生育酚水平的平均增幅明显更大（73％对-4.6％，P <0.0001），但氧化的LDL没有明显变化。结论：退伍军人的二级预防试验是可行的，因为登记率，完成率，依从性和临床事件发生率很高。 α-生育酚补充剂并未降低LDL对氧化的敏感性，这表明二级预防可能需要更高剂量或更长的补充时间。版权所有1999美国健康基金会和学术出版社。

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