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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Indices related to apo CII and CIII serum concentrations and coronary heart disease: a case-control study.
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Indices related to apo CII and CIII serum concentrations and coronary heart disease: a case-control study.

机译:与载脂蛋白CII和CIII血清浓度及冠心病有关的指标:病例对照研究。

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BACKGROUND: Triglycerides (TG) are carried in the circulation by diverse lipoprotein particles, which vary in their lipid and protein content, metabolism, and atherogenicity. Several indices related to apolipoproteins (apo) CII and CIII blood concentration have been proposed to reflect TG metabolism more accurately than the blood level of TG. In the present study we compared the distribution of those indices in coronary heart disease (CHD) patients and controls.. METHODS: Ninety consecutively discharged patients with CHD and 209 healthy controls were included in the analysis. Demographic, clinical, and laboratory characteristics were obtained. RESULTS: The CHD patients differed appreciably from controls in several TG-related variables. After adjusting for cardiovascular risk factors, significant associations were found between CHD and the following: TG, VLDL-C, apo CIII, apo CIII in HDL, apo CIII in VLDL + LDL, apo CII- to- TG ratio, and apo CIII ratio (CIII in HDL/CIII in VLDL + LDL). Further adjustment for HDL-C substantially attenuated the above associations, except for those regarding apo CIII in VLDL + LDL (odds ratio (OR): 1.69 per 1 SD increment, 95%CI: 1.03-2.77) and apo CIII ratio (OR: 0.40 per 1 SD increment, 95%CI: 0.15-1.00). CONCLUSION: Our results add to the growing evidence which links apo CIII concentration in VLDL + LDL to CHD. Further confirmation in prospective studies would be required before considering this measurement as a screening tool.
机译:背景:甘油三酸酯(TG)由多种脂蛋白颗粒携带在循环系统中,这些脂蛋白颗粒的脂质和蛋白质含量,代谢和动脉粥样硬化性均发生变化。已经提出了几种与载脂蛋白(apo)CII和CIII血液浓度有关的指标,以比TG的血液水平更准确地反映TG的代谢。在本研究中,我们比较了那些指数在冠心病(CHD)患者和对照组中的分布。方法:分析包括90例连续出院的CHD患者和209名健康对照。获得了人口统计学,临床和实验室特征。结果:冠心病患者在几个与TG有关的变量方面与对照组明显不同。调整心血管危险因素后,发现冠心病与以下因素之间存在显着相关性:TG,VLDL-C,apo CIII,HDL中的apo CIII,VLDL + LDL中的apo CIII,apo CII与TG的比率以及apo CIII比率(HDL中的CIII / VLDL + LDL中的CIII)。除VLDL + LDL中的载脂蛋白CIII(奇数比(OR):每1 SD增量1.69,95%CI:1.03-2.77)和载脂蛋白CIII比率(OR:每1 SD增量0.40,95%CI:0.15-1.00)。结论:我们的结果增加了将VLDL + LDL中载脂蛋白CIII浓度与冠心病联系起来的越来越多的证据。在考虑将此测量作为筛选工具之前,需要在前瞻性研究中进一步确认。

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