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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Low-density lipoprotein cholesterol and risk of coronary heart disease among Japanese men and women: the Circulatory Risk in Communities Study (CIRCS).
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Low-density lipoprotein cholesterol and risk of coronary heart disease among Japanese men and women: the Circulatory Risk in Communities Study (CIRCS).

机译：低密度脂蛋白胆固醇和日本男性和女性冠心病的风险：社区循环风险研究（CIRCS）。

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OBJECTIVE: The objective of this study was to assess the association between serum LDL-cholesterol levels and risk of coronary heart disease (CHD) among Japanese who have lower means of LDL-cholesterol than Western populations. METHODS: The predictive power of estimated serum LDL-cholesterol levels in casual blood samples for risk of CHD was evaluated among residents from four Japanese communities participating in the Circulatory Risk in Communities Study (CIRCS). A total of 8131 men and women, aged 40 to 69 years with no history of stroke or CHD, completed baseline risk factor surveys between 1975 and 1987. By 2003, 155 cases of incident CHD (myocardial infarction, angina pectoris and sudden cardiac death) had been identified. RESULTS: Mean LDL-cholesterol values were 99.4 mg/dL for men and 109.4 mg/dL for women. The crude incidence rate (per 100,000 person-years) of CHD was 152.0 for men and 51.9 for women. The respective multivariable hazard ratios for >/= 140 mg/dL versus <80mg/dL LDL-cholesterol were 2.80 (95% confidence interval: 1.59 to 4.92) for total CHD, 3.83 (1.78-8.23) for myocardial infarction, 4.07 (2.02-8.20) for non-fatal CHD, and 1.24 (0.44-3.47) for fatal CHD. CONCLUSION: Serum LDL-cholesterol levels ranging from around 80 mg/dL to 200mg/dL were positively associated with risk of CHD in a Japanese population.
机译：目的：本研究旨在评估低密度脂蛋白胆固醇水平低于西方人群的日本人的血清低密度脂蛋白胆固醇水平与冠心病（CHD）风险之间的关系。方法：在参加社区循环风险研究（CIRCS）的四个日本社区的居民中，评估了偶然血液样本中血清低密度脂蛋白胆固醇水平对冠心病风险的预测能力。 1975年至1987年之间，共有8131名年龄在40至69岁，无中风或冠心病史的男性和女性完成了基线危险因素调查。到2003年，有155例冠心病事件（心肌梗塞，心绞痛和心源性猝死）已被确定。结果：男性平均LDL-胆固醇值为99.4 mg / dL，女性为109.4 mg / dL。冠心病的粗略发病率（每100,000人年）男性为152.0，女性为51.9。 > / = 140 mg / dL与<80mg / dL LDL-胆固醇的多变量危险比分别为CHD的2.80（95％置信区间：1.59至4.92），心肌梗塞的3.83（1.78-8.23），4.07（2.02）对于非致命性CHD，则为-8.20），对于致命性CHD，则为1.24（0.44-3.47）。结论：日本人群血清低密度脂蛋白胆固醇水平在80 mg / dL至200mg / dL之间与CHD风险呈正相关。

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