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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Weight and metabolic effects of dietary weight loss and exercise interventions in postmenopausal antidepressant medication users and non-users: A randomized controlled trial
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Weight and metabolic effects of dietary weight loss and exercise interventions in postmenopausal antidepressant medication users and non-users: A randomized controlled trial

机译：绝经后抗抑郁药物使用者和非使用者饮食减肥和运动干预对体重和代谢的影响：一项随机对照试验

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Objective: Antidepressants may attenuate the effects of diet and exercise programs. We compared adherence and changes in body measures and biomarkers of glucose metabolism and inflammation between antidepressant users and non-users in a 12-month randomized controlled trial. Methods: Overweight or obese, postmenopausal women were assigned to: diet (10% weight loss goal, N = 118); moderate-to-vigorous aerobic exercise (225. min/week, N = 117); diet. +. exercise (N = 117); and control (N = 87) in Seattle, WA 2005-2009. Women using antidepressants at baseline were classified as users (N = 109). ANCOVA and generalized estimating equation approaches, respectively, were used to compare adherence (exercise amount, diet session attendance, and changes in percent calorie intake from fat, cardiopulmonary fitness, and pedometer steps) and changes in body measures (weight, waist and percent body fat) and serum biomarkers (glucose, insulin, homeostasis assessment-insulin resistance, and high-sensitivity C-reactive protein) between users and non-users. An interaction term (intervention × antidepressant use) tested effect modification. Results: There were no differences in adherence except that diet session attendance was lower among users in the diet+exercise group (P0.05 vs. non-users). Changes in body measures and serum biomarkers did not differ by antidepressant use (Pinteraction0.05). Conclusion: Dietary weight loss and exercise improved body measures and biomarkers of glucose metabolism and inflammation independent of antidepressant use.
机译：目的：抗抑郁药可能会削弱饮食和锻炼计划的效果。在一项为期12个月的随机对照试验中，我们比较了抗抑郁药使用者与非使用者之间的依从性，身体测量指标以及葡萄糖代谢和炎症的生物标志物的变化。方法：将超重或肥胖，绝经后的妇女分配为饮食（减肥目标为10％，N = 118）;中度至剧烈的有氧运动（225分钟/周，N = 117）;饮食。 +。锻炼（N = 117）;和控制（N = 87），西雅图，华盛顿州2005-2009。在基线时使用抗抑郁药的妇女被归类为使用者（N = 109）。分别使用ANCOVA和广义估计方程方法来比较依从性（运动量，饮食锻炼出席率以及脂肪，心肺健康度和计步器步数所产生的卡路里摄入百分比变化）和身体测量值（体重，腰围和身体百分比）的变化使用者与非使用者之间的脂肪和血清生物标志物（葡萄糖，胰岛素，体内稳态评估-胰岛素抵抗以及高敏感性C反应蛋白）。相互作用项（干预×抗抑郁药的使用）测试了效果的改善。结果：饮食加运动组的使用者饮食饮食出席率较低（P <0.05 vs.非使用者），依从性没有差异。服用抗抑郁药后，身体指标和血清生物标志物的变化无差异（交互作用> 0.05）。结论：饮食减肥和锻炼可改善身体状况，并改善葡萄糖代谢和炎症的生物标志物，而与使用抗抑郁药无关。

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