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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Identifying adolescents with high fasting glucose: The importance of adding grandparents' data when assessing family history of diabetes
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Identifying adolescents with high fasting glucose: The importance of adding grandparents' data when assessing family history of diabetes

机译：识别高空腹血糖的青少年：评估糖尿病家族史时添加祖父母数据的重要性

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Objective: To evaluate the role of adding grandparents' data to parental information to the assessment of a family history of diabetes, in order to identify adolescents with high fasting glucose. Method: In 2003 we evaluated 1276 population-based 13-year-olds, from Porto, Portugal. The history of diabetes in parents and grandparents was collected using self-reported questionnaires and a clinical evaluation was performed, including a fasting blood sample. The 75th percentile of fasting plasma glucose (FPG = 91. mg/dl) was used to create two groups of participants (high vs. low fasting glucose). Results: No association was found between family history of diabetes (with or without grandparental data) and a high FPG. The sensitivity to identify individuals with high FPG increased from 7.8% to 47.9% when grandparental history was combined with parental data. The positive predictive value was slightly increased (25.2% vs. 27.8%) but the specificity dropped (91.8% vs. 56.4%). Conclusion: Combining parental with grandparental history increased the number of adolescents with a positive family history of diabetes and also increased the sensitivity to identify adolescents with high FPG. So, even if it determines a decrease in specificity, grandparental data is relevant when screening for high fasting glucose in adolescents.
机译：目的：评估将祖父母的数据添加到父母的信息中对评估糖尿病家族史的作用，从而确定空腹血糖高的青少年。方法：2003年，我们评估了来自葡萄牙波尔图的1276名以人群为基础的13岁儿童。使用自我报告的问卷收集父母和祖父母的糖尿病史，并进行临床评估，包括空腹抽血。空腹血糖的第75个百分位（FPG = 91. mg / dl）用于创建两组参与者（高空腹血糖与低空腹血糖）。结果：未发现糖尿病家族史（有或没有祖父母数据）与高FPG之间存在关联。当祖父母的病史与父母的数据相结合时，识别高FPG个体的敏感性从7.8％增加到47.9％。阳性预测值略有增加（25.2％对27.8％），但特异性下降（91.8％对56.4％）。结论：将父母与祖父母的病史结合起来可增加青少年糖尿病家族史阳性的青少年人数，并增加识别高FPG青少年的敏感性。因此，即使确定特异性降低，在筛查青少年的高空腹血糖时，祖父母数据也很重要。

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